Genetic linkage analysis is a powerful tool to detect the chromosomal location of disease genes. It is based on the observation that genes that reside physically close on a chromosome remain linked during meiosis. For most neurologic diseases for which the underlying biochemical defect was not known, the identification of the chromosomal location of the disease gene was the first step in its ev...

IIIStatistical properties of the method of lod scores III1. The test procedure III1.1. Impact of non-sequentiality III1.2. Maximization of the lod score over the [0, 1/2] interval III1.3 References III-2. Genotype information III-2.1. Ambiguity in phenotype-genotype relationships at the disease locus III-2.2. Ambiguity in the marker genotype III-2.3. Gamete disequilibrium between alleles at the...

Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic nephropathy, which is characterized by replacement of renal parenchyma with multiple cysts. In Iran, the disease prevalence within the chronic hemodialysis patient population is approximately 8-10%. So far, three genetic loci have been identified to be responsible for ADPKD. Little information is available concernin...

Self-sensing refers to extracting the position information from the electromagnetic signals instead of from a physical position sensor. Self-sensing actuator has the benefit of significantly reducing hardware effort. In this paper, we investigate selfsensing actuators applied in direct acing proportional valves. The study is based on the configuration of a dual-solenoid actuator where each sole...

In this paper a low-cost sensorless control strategy of SR motor is proposed. The static flux-linkage characteristics of the motor are used for estimating the position. A number of discrepancies between the static and the dynamic characteristics of the motor are explained. In this paper the issues regarding eddy effects and mutual inductances in both static and dynamic conditions, and their inf...