BACKGROUND Although individuals with diabetes mellitus frequently have dyslipidaemias and high blood pressure, much of the increased risk for coronary heart disease is not explained by these and other classical risk factors. Thus, other less widely recognized risk factors, including increased susceptibility of low-density lipoprotein (LDL) to oxidation, might enhance vascular dysfunction and at...

Pacu ( Piaractus mesopotamicus ) is one of the most important fish farmed species in Brazil due to its hardy, fast growing, omnivorous feeding behavior, and good consumers acceptance. However, studies on effect different slaughtering procedures quality frozen pacu fillets have not been carried out. Therefore, this study aimed evaluate electrical stunning, CO 2 narcosis, or water/ice immersion (...

Although peroxisomes oxidize lipids, the metabolism of lipid bodies and peroxisomes is thought to be largely uncoupled from one another. In this study, using oleic acid-cultured Saccharomyces cerevisiae as a model system, we provide evidence that lipid bodies and peroxisomes have a close physiological relationship. Peroxisomes adhere stably to lipid bodies, and they can even extend processes in...

The capacity of Al3+ to promote oxidative damage to brain membranes was investigated both in vitro and in vivo. In vitro, Al3+ and related metals (Sc3+, Ga3+, In3+, Be2+, Y3+, and La3+) stimulated Fe2+-initiated lipid and protein oxidation in brain myelin and synaptic membranes. Al3+, Sc3+, Y3+, and La3+ significantly promoted protein-associated carbonyl production in myelin, while in synaptic ...

Abstract Sensory properties of foods mainly affect purchasing decisions. In case sausages, deterioration pigments meat and spices cause discolouration, while lipid oxidation leads to the formation off-odours, these two processes are connected. Lipid promotes conversion pigments, metmyoglobin accelerates oxidation. The scope study was investigate relationship between amount malondialdehyde equiv...

Oxidative modification of low density lipoprotein (LDL) has been suggested to play a casual role in human atherosclerosis, and prevention of LDL oxidation may be an effective strategy to prevent or slow the progression of this disease. It is important, therefore, to identify the factors that determine LDL's susceptibility to oxidation. We have analyzed 62 human LDL samples for content of antiox...

The impact of type 2 diabetes (T2D) on the ability of muscle to accumulate and dispose of fatty acids and triglycerides (TG) was evaluated in cultured muscle cells from non-diabetic (ND) and Type 2 diabetic (T2D) subjects. In the presence of 5 µM palmitate T2D muscle cells accumulated less lipid than ND cells (11.5±1.2 vs 15.1±1.4 nmol/mg protein, p<0.05). Chronic treatment (4 d) with a PPAR ag...

The impact of type 2 diabetes on the ability of muscle to accumulate and dispose of fatty acids and triglycerides was evaluated in cultured muscle cells from nondiabetic (ND) and type 2 diabetic (T2D) subjects. In the presence of 5 microM palmitate, T2D muscle cells accumulated less lipid than ND cells (11.5 +/- 1.2 vs. 15.1 +/- 1.4 nmol/mg protein, P < 0.05). Chronic treatment (4 days) with th...