نتایج جستجو برای: lipinski
تعداد نتایج: 185 فیلتر نتایج به سال:
When Emil Kraeplin in .1899 gave the clinical description of the two psychoses 'Dementia Praccox" and 'Manic-Depressive Insanity,' he laid not only the foundation of our modern psychiatric taxonomy, but also the roots of our present diagnostic difficulties concerning the clinical forms which do not entirely meet the criteria required for inclusion in one or other of the two groups. Several work...
iii iv Acknowledgement This thesis has been elaborated at the Institut für Neuroinformatik at the Ruhr-University Bochum. Working at the Institut für Neuroinformatik has been a huge chance that allowed me to discover the pleasure of interdisci-plinary and exciting scientific work. Advised by Gregor Schöner I experienced a way of doing research that I find very beautiful because of its conceptua...
BACKGROUND The recent public availability of the human metabolome and natural product datasets has revitalized "metabolite-likeness" and "natural product-likeness" as a drug design concept to design lead libraries targeting specific pathways. Many reports have analyzed the physicochemical property space of biologically important datasets, with only a few comprehensively characterizing the scaff...
We report a method to determine propagation delays of optical 10 Gb/s data traveling through a 75 km long amplified fiber link with an uncertainty of 4 ps. The one-way propagation delay is determined by twoway exchange and cross correlation of short (< 1 ms) bursts of 10 Gb/s data, with a single-shot time resolution better than 2.5 ps. We thus achieve a novel optical communications link suited ...
The process of compound selection and prioritization is crucial for both combinatorial chemistry (CBC) and high throughput screening (HTS). Compound libraries have to be screened for unwanted chemical structures, as well as for unwanted chemical properties. Property extrema can be eliminated by using property filters, in accordance with their actual distribution. Property distribution was exami...
Rationale: Complementation of pluripotency genes may improve adult stem cell functions. Objectives: Here we show that clonally expandable, telomerase expressing progenitor cells can be isolated from peripheral blood of children. The surface marker profile of the clonally expanded cells is distinct from hematopoietic or mesenchymal stromal cells, and resembles that of embryonic multipotent mesoa...
a variety of reasons, did not come under federal law until the Sound Recording Act of 1972. Though certainly a milestone in the record industry’s efforts to quash piracy, Cummings notes that this new law was a harbinger of more changes to come, and it “marked a turning point in American thought about culture, technology, and property” of all types. As the Copyright Act of 1976 and subsequent la...
TOPIC: Diffuse Lung Disease TYPE: Fellow Case Reports INTRODUCTION: Electroconvulsive therapy (ECT) has been increasingly used over the last few years for various indications, of rare complications described in literature is pulmonary edema, only 9 case reports this complication, 8 which were attributed to none cardiogenic cause and one had a cardiology component. Here we present edema diffuse ...
A series of piperonal chacones bearing schiff base moiety were designed and docked in to colchicine binding site of tubulin using the podophyllotoxin-tubulin complex (PDB 1SA1) as template. Docking study reveals that few of the designed derivatives were found to have significant interaction with active site of the receptor. The derivatives with trimethoxyphenyl ring, amino phenyl & nitro phenyl...
BACKGROUND & OBJECTIVES Cysteine proteases (falcipains), a papain-family of enzymes of Plasmodium falciparum, are responsible for haemoglobin degradation and thus necessary for its survival during asexual life cycle phase inside the human red blood cells while remaining non-functional for the human body. Therefore, these can act as potential targets for designing antimalarial drugs. The P. falc...
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