Lipoproteins, isolated by sequential flotation at densities 1.006, 1.019, 1.063, and 1.21, were examined for their ability to inhibit human lymphocytes stimulated by allogeneic cells and by lectins (phytohemagglutinin-P and concanavalin A). All the classes of normal plasma lipoproteins inhibited lymphoproliferation when peripheral blood lymphocytes were cultured in autologous, heterologous, or ...

Canine plasma lipoproteins were fractionated into four distinct classes by ultracentrifugation combined with Geon-Pevikon block electrophoresis and characterized with respect to physical and chemical properties. The distribution of plasma lipids and lipoproteins was quite unlike that in man, the dog having approximately five to six times as much high density as lower density lipoproteins. Despi...

We have developed a double antibody radioimmunoassay (RIA) for human apolipoprotein B (ApoB). The assay measures not only the ApoB content of beta-lipoproteins (low density lipoproteins [LDL]) but also that contained in the other lipoproteins in plasma. Purified lymph and plasma chylomicrons and plasma very low density lipoproteins (VLDL) produced displacement curves in the assay system which p...

To evaluate the concentrations of serum lipids and lipoproteins and their correlations together and withthyroid hormones in gray necked ostrich (Struthio camelus), the serum levels of cholesterol, triglyceride,total lipids, very low density lipoproteins (VLDL-cholesterol), low density lipoproteins (LDL-cholesterol)and high density lipoproteins (HDL-cholesterol) and their correlations with tri-i...

Apolipoprotein AII (apoAII) transgenic (apoAIItg) mice exhibit several traits associated with the insulin resistance (IR) syndrome, including IR, obesity, and a marked hypertriglyceridemia. Because treatment of the apoAIItg mice with rosiglitazone ameliorated the IR and hypertriglyceridemia, we hypothesized that the hypertriglyceridemia was due largely to overproduction of very low density lipo...

The TCF7L2 rs7903146 T-allele shows the strongest association with type 2 diabetes (T2D) among common gene variants. The aim of this study was to assess circulating levels of metabolites following a meal test in individuals carrying the high risk rs790346 TT genotype (cases) and low-risk CC genotype (controls). Sixty-two men were recruited based on TCF7L2 genotype, 31 were TT carriers and 31 we...

three centrifugations (gel I). Rather, we believe that successive centrifugation of large chylomicrons for 6 x 10' gmin results in their purification with loss of VLDL and small chylomicrons containing apo B100. The results demonstrate that purified large chylomicrons contain apo B-48, but do not contain apo B100 and that the apo B-1 00 in chyle is located in the small chylomicron and VLDL frac...

to evaluate the correlations of the serum concentrations of trace elements with lipids and lipoproteins in water buffalo (bubalus bubalis), the serum concentrations of cholesterol, triglyceride, total lipids, very low density lipoproteins (vldl-cholesterol), low density lipoproteins (ldl-cholesterol) and high density lipoproteins (hdl-cholesterol) and their correlations with serum concentration...

Model structure and boundaries The sub-models are divided into 8 by 40 and 40 by 8 compartments of lipoprotein composition, which throughout the supplemental material will be referred to as cells. The metabolism of lipoproteins in cell (i ,j) can be described by equation (1) for cells in the HDL grid and by equation (2) if the cell is in the VLDL grid (see equations (9) and (11) in the Main Tex...