The capacity of liquid chromatography-tandem mass spectrometry (LC-MS2) to detect and define individual components in a complex mixture has been utilized to develop a quantitative assay of the potent immunosuppressant drug, tacrolimus. Trough blood concentrations were measured in 175 samples obtained over several weeks after liver transplantation from seven patients. The assay was linear over t...

Abstract Background Hepatocellular carcinoma (HCC) is the fifth most frequent cancer on world. Fat accumulation within hepatocytes known as hepatic steatosis. In recent years, research has found that people with non-alcoholic fatty liver disease have a higher chance of developing HCC. The LI-RADS ® (Liver Imaging Reporting and Data System) was created to facilitate consistent reporting imaging ...

BACKGROUND AND OBJECTIVES Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) has been established as a safe and accurate method for diagnosing and staging intra-abdominal mass. However, few studies investigated its feasibility, efficacy, and safety for targeting liver mass. We evaluated the efficacy and safety of EUS-FNA in patients with liver masses including the right lobe. PATIE...

results rbp4 levels in obese children (19 482.9 ± 3 302.2 pg/ml) were higher than those found in the lean control group (14 295.68 ± 2 381.3 pg/ml) (p < 0.05). in the obese patients, rbp4 levels showed a significant correlation with the grade of fatty liver and bmi (p < 0.05). conclusions it was found that the level of rbp4 had a strong correlation with the severity of fatty liver. therefore, r...

The liver serves a spectrum of essential metabolic and synthetic functions that are required for the transition from fetal to postnatal life. Processes essential to the attainment of adequate liver mass and function during fetal life include cell lineage specification early in development, enzymic and other functional modes of differentiation throughout gestation, and ongoing cell proliferation...

BACKGROUND Differentiation of malignant from benign liver tumors remains a challenging problem. In recent years, mass spectrometry (MS) technique has emerged as a promising strategy to diagnose a wide range of malignant tumors. The purpose of this study was to establish classification models to distinguish benign and malignant liver tumors and identify the liver cancer-specific peptides by mass...

The glucose-6-phosphatase system catalyses the terminal step of hepatic glucose production from both gluconeogenesis and glycogenolysis and is thus a key regulatory factor of blood glucose homoeostasis. To identify the glucose 6-phosphate transporter T1, we have performed photoaffinity labelling of human and rat liver microsomes by using the specific photoreactive glucose-6-phosphate translocas...

Chlordecone (CLD) is an organochlorine pesticide widely used from the 1970s to 1990s in French West Indies that induced long-term pollution of ecosystem. Due involuntary soil ingestion, some species bred open-air areas can be contaminated. As CLD distributed various tissues depending on breeding species, this study focuses distribution bovines. For purpose, three tissues, i.e. fat, muscle, and ...

Inflammatory pseudotumor is increasingly being recognized as a definitive pathological entity affecting many organ systems and often difficult to distinguish from malignancy. We report case of 48-year-old female who presented with right hypochondrial pain associated nausea vomiting recent weight loss. An ultrasound scan demonstrated gallstones without evidence cholecystitis an incidental 1.5 cm...