Abstract A 58‐year‐old man was referred to our hospital with right abdominal pain. Contrast‐enhanced computed tomography (CECT) showed a rim‐enhanced lesion fluid collection in the hepatic lobe. Upper gastrointestinal endoscopy revealed Borrmann type 1 tumor on middle gastric body, identified as an adenocarcinoma pathology. The patient underwent percutaneous transhepatic abscess drainage and tr...

Alzheimer’s disease (AD) is a progressive brain disorder characterized by extracellular amyloid-β (Aβ) plaques, intracellular neurofibrillary tangles formed hyperphosphorylated Tau protein and neuroinflammation. Previous research has shown that obesity type 2 diabetes mellitus, underlined insulin resistance (IR), are risk factors for neurodegenerative disorders. In this study, obesity-induced p...

The oxidant source in alcohol-induced liver disease remains unclear. NADPH oxidase (mainly in liver Kupffer cells and infiltrating neutrophils) could be a potential free radical source. We aimed to determine if NADPH oxidase inhibitor diphenyleneiodonium sulfate (DPI) affects nuclear factor-kappaB (NF-kappaB) activation, liver tumor necrosis factor-alpha (TNF-alpha) mRNA expression, and early a...

Neoplastic Mimics in Dermatopathology is part of the Pathology of Neoplastic Mimics Series, which includes Thoracic and Cardiovascular Pathology and Genitourinary Pathology. Forthcoming volumes include Breast Pathology, Gastrointestinal and Liver, Gynecologic Pathology, Head and Neck Pathology and Bone and Soft Tissue Pathology. I had not had the opportunity to read any of these books until now...

T-bet and STAT1 regulate IFN-gamma gene transcription in CD4+ T cells, which mediate protection against Leishmania. Here we show that T-bet and STAT1 are required for the induction of an efficient Th1 response during Leishmania donovani infection, but they play distinct roles in determining disease outcome. Both STAT1(-/-) and T-bet(-/-) mice failed to mount a Th1 response, but STAT1(-/-) mice ...

Right upper quadrant pain is a common presenting complaint to the general and hepatobiliary surgical team. Differential diagnoses include gallstones, cholecystitis, liver and pancreatic pathology. A 64-year-old man presented to our general surgical unit with right upper quadrant pain and deranged liver function tests. He underwent ultrasonography several times as well as magnetic resonance chol...

background aging causes many changes in human physiology, increasing the risk of pathologic conditions in elderly populations. different studies have shown higher frequency of oral and maxillofacial lesions in older people. knowing the prevalence and distribution of these lesions can help dentists in screening these patients. objectives this study aimed to evaluate the frequency and distributio...