Alzheimer's disease (AD) is a chronic neurodegenerative disease which contributes to memory loss and cognitive decline in the elderly. Fucoidan, extracted from brown algae, is a complex sulfated polysaccharide and potential bioactive compound. In this study, we investigated whether fucoidan protects PC12 cells from apoptosis induced by a combination of beta-amyloid 25-35 (Aβ25-35) and d-galacto...

The tendency of certain individuals to repeated attacks of pneumonia has at times given rise to doubt whether acquired immunity to pneumonia exists. Considerable evidence, however, can be brought forward to show that a rather high degree of immunity to the pneumococcus follows an attack of pneumonia. The crisis itself is a striking expression of immunity. Furthermore, Dochez 1 has shown that th...

Caspases and inhibitor of apoptosis proteins (IAPs) are antagonizing key apoptosis regulators. Limited studies of a few IAPs indicated their roles in astrocytomas. However, the overall expression status and significance of apoptosis regulators in astrocytomas is not clear. We examined the expression profile of the caspases (CASP3, 6, 7, 8, 9, 10, and 14), APAF1, SMAC, BCL2, the IAPs (BIRC5/surv...

Pef6eived· ~ontrol, perceived choice, and residential setting are ~important factors which need to be addressed in research i n v.iJ l vi n g " the 1 on g -1 iv in g . The focus o f th i s s t u d y was t o determine the relationships among these variables. The s~~fch fo~ an inter~ction between residential setting (eft her high or low constraining) and perceived choice and {ts effect on perceiv...

Melanoma arises from neural crest-derived melanocytes which reside mostly in the skin in an adult organism. Epithelial-mesenchymal transition (EMT) is a tumorigenic programme through which cells acquire mesenchymal, more pro-oncogenic phenotype. The reversible phenotype switching is an event still not completely understood in melanoma. The EMT features and increased invasiveness are associated ...

Autoantibodies (AAbs) to tumor-associated antigens (TAAs) have been identified in the sera of cancer patients. In a previous review published in this journal, we have focused on recent knowledge related to circulating AAbs to individual TAAs in breast carcinoma. This review will focus on recent knowledge related to AAb assays to tailor-made panels of TAAs in breast carcinoma. So far, AAb assays...