Immune checkpoint inhibitors (ICI), monoclonal antibodies against PD-1/PD-L1, have improved the survival of patients with metastatic non-small cell lung cancer (mNSCLC). Tumor expression PD-L1 is currently only approved biomarker for ICI selection. It does not describe complex interaction between immune cells and tumor in microenvironment (TME) an imperfect biomarker. We used multiplex fluoresc...

background: cervical cancer has been shown to be highly associated with human papillomavirus (hpv) infection. the viral oncogenes e6 and e7 are constantly expressed by the tumor cells and are therefore potent targets for therapeutic genetic vaccination. in the present study, it was investigated the potential effect of hpv-16 e6, e7 and l1 co-administration to activate specific cytotoxic t lymph...

abstract background ulcerative colitis (uc) is characterized by recurrent episodes of inflammation limited to the mucosal layer of the colon. calprotectin is a zinc and calcium binding protein derived from neutrophils and monocytes. it is easily detectable in tissue samples, body fluids, and stools, which makes it a potentially valuable marker of inflammation. the aim of the current study is to...