Cough and airway constriction are common features of respiratory diseases. Both can be caused by stimulation of airway nerves. We have studied the effects of airway anaesthesia on these reflexes, stimulated by inhaled capsaicin, in order to determine whether they are controlled by the same sensory nerves. Ten volunteers had capsaicin cough dose responses performed before and at 10 min after inh...

The in vitro sensitivities to local anaesthetic blockade of A, B and C nerve fibres in rabbit vagus nerves were examined using a series of structurally similar amino-ester agents which varied in lipid solubility and anaesthetic potency. A fibres were found to be the most sensitive and C fibres the least sensitive to conduction blockade with all the agents, provided that equilibrium blockade was...

in this study the effects of the most popular anaesthetics including: ms222, clove oil (eugenia caryophyllata) and 2-phenoxyethanol, on some haematological and serum enzymes of cyprinus carpio were investigated. firstly the effective dose of each anaesthetics (3 minutes for anesthesia and 5 minutes for recovery ) and lc50 of them were calculated in c. carpio. fish were anaesthetized with the ef...

Since the discovery of the anaesthetic effect of cocaine in 1884, local anaesthetics (LAs) have been widely used. It has been estimated that 6 million people are injected with LAs each day around the world. In spite of their widespread use, true hypersensitivity appears to be infrequent. However the perception of allergy to LA among the general public is high. In our drug allergy clinic, referr...

Background: Local anesthetics (LA) are frequently used in dentistry. Although these drugs are usually well-tolerated, they can sometimes provoke adverse reactions of various types and severity. The true incidence of LA allergic reactions is unknown. The objectives of this study were (i) to evaluate the incidence of immediate adverse events in subjects requiring local anesthetic injection in ord...

Editor—We read with interest the case report by Satsumae and colleagues, addressing the question of sensitivity to local anaesthetics (LAs) with toxicity occurring at a lower than expected dose. We encountered a similar case in a 51-yr-old woman who presented with generalized myoclonic movements after a popliteal-sciatic blockade with a non-stimulating catheter, inserted with a peripheral nerve...

Pain relief may be improved by reducing sensitization of nociceptive pathways caused by tissue injury. Such a reduction depends mainly on inhibition of local inflammatory changes and the relation between duration of nociceptive block and nociceptive input. In this study we examined if prolonged topical treatment with local anaesthetics could reduce late hyperalgesia and local inflammation after...