Background: The primary phase of traumatic spinal cord injury (SCI) starts by a complex local inflammatory reaction such as secretion of pro-inflammatory cytokines from microglia and injured cells that substantially contribute to exacerbating pathogenic events in secondary phase. Valproic acid (VPA) is a histone deacetylase inhibitor. Acetylation of histones is critical to cellular inflammatory...

Community structure is vital to discover the important structures and potential property of complex networks. In recent years, the increasing quality of local community detection approaches has become a hot spot in the study of complex network due to the advantages of linear time complexity and applicable for large-scale networks. However, there are many shortcomings in these methods such as in...

In this work, a new mathematical model of thermoelasticity theory has been considered in the context of a new consideration of heat conduction with fractional order theory. A functionally graded isotropic unbounded medium is considered subjected to a periodically varying heat source in the context of space-time non-local generalization of three-phase-lag thermoelastic model and Green-Naghdi mod...

in this paper, a two-phase algorithm, namely ivns, is proposed for solving nonlinear optimal control problems. in each phase of the algorithm, we use a variable neighborhood search (vns), which performs a uniform distribution in the shaking step and the successive quadratic programming, as the local search step. in the first phase, vns starts with a completely random initial solution of control...

Local hardness increasing on the surface of the power plant rotor may result in severe damages. One major solution for rapid repairing of the rotors is the adaptive tempering heat treatment. For this purpose, after identification of the damaged rotor, initial investigations and tests (such as visual inspection, chemical analysis, nondestructive hardness measurements and replica or on-site metal...

In this study, a two phase hybrid heuristic approach was proposed to solve the multi-depot multi-vehicle inventory routing problem (MDMVIRP). Inventory routing problem (IRP) is one of the major issues in the supply chain networks that arise in the context of vendor managed systems (VMI) The MDMVIRP combines inventory management and routing decision. We are given on input a fleet of homogeneous ...

Introduction: Direction and latency of electrical connectivity between different sites of brain explains brain neural functionality. We compared efficiency of cross correlation and phase locking methods in time lag estimation which are based on local field potential (LFP) and LFPspike signals, respectively. Methods: Signals recorded from MT area of a macaque’s brain was used in a simulation ...

We investigate the relationship between two kinds of ground-state local convertibility and quantum phase transitions in XY model. The local operations and classical communications (LOCC) convertibility is examined by the majorization relations and the entanglement-assisted local operations and classical communications (ELOCC) via Rényi entropy interception. In the phase diagram of XY model, LOC...