Herein, we report a case of paraneoplastic pemphigus with mild skin features of pemphigus foliaceus and lichenoid stomatitis associated with B-cell lymphoma. A 49-year-old man presented with scattered blisters and erosions on the trunk along with mucosal blisters and erosions. Skin biopsy showed subcorneal acantholytic bulla and oral mucosal biopsy demonstrated lichenoid dermatitis. Direct immu...

Introduction: The in situ immune response in skin biopsies from patients affected by autoimmune skin blistering diseases (ABD) is not well characterized. Aim: Our investigation attempts to immunophenotype cells in lesional skin in several ABD, utilizing immunohistochemistry (ICH). Methods: We tested by IHC for CD4, CD8, CD19, CD20, CD45, CD56/NCAM, PAX-5, granzyme B, myeloperoxidase, neutrophil...

Introduction: Previous research on autoimmune skin blistering diseases (ABD) has primarily focused on the humoral immune response; moreover, little attention has been given to the potential role of the antigen presenting cells (APCs) in lesional skin. Aim: The purpose of our study was to immunophenotype selected APC in the lesional skin of ABDs, utilizing immunohistochemistry (IHC) stains. Mate...

ALTHOUGH there are numerous reports of individual cases, only a few papers deal with general aspects of the clinical picture of generalized vaccinia (Tedder, I936; Clark, Seiler, Joe, Gammie, Tait and Jack, I944; Fries, Borne and Barnes, I948). During two outbreaks of generalized vaccinia occurring, after two mass vaccinations, in a hospital for patients with pemphigus foliaceus, some clinical ...

CYP: cytochrome P INTRODUCTION Pemphigus foliaceus is a rare autoimmune bullous dermatosis that can be induced by drugs, with variable duration lasting between several weeks and months. Erythematous scaly patches develop on the scalp, face, neck or chest. The use of oral or topical herbal supplements to improve health has increased in the last decades. These preparations may trigger multiple ad...

BACKGROUND Rituximab, a monoclonal anti-CD20 antibody, has been used with encouraging results in pemphigus. We describe herein refractory cases of pemphigus vulgaris (n = 23) and pemphigus foliaceus (n = 1) treated with rituximab in addition to steroids and immunosuppressants. AIMS To assess the response to treatment, the duration of clinical remission, serology of the response and adverse ef...