The role of clathrin in the sorting of proinsulin to secretory granules, the formation of immature granules and their subsequent maturation is not known. To this end, primary rat pancreatic beta-cells were infected with a recombinant adenovirus co-expressing the Hub fragment, a dominant-negative peptide of the clathrin heavy chain and enhanced green fluorescent protein (EGFP as a marker of infe...

We evaluate the performance of a Fast Ethernet network configured with a single large switch, a single hub, and a 4x4 2D torus topology in a testbed cluster of “commodity” Pentium Pro PCs. We also evaluated a mixed network composed of ethernet hubs and switches. An MPI collective communication benchmark, and the NAS Parallel Benchmarks version 2.2 (NPB2) show that the torus network performs bes...

We evaluate the performance of a Fast Ethernet network configured with a single large switch, a single hub, and a 4x4 2D torus topology in a testbed cluster of “commodity” Pentium Pro PCs. We also evaluated a mixed network composed of ethernet hubs and switches. An MPI collective communication benchmark, and the NAS Parallel Benchmarks version 2.2 (NPB2) show that the torus network performs bes...

In contrast to p-hub problems with a summation objective (p-hub median), minmax hub problems (p-hub center) have not attained much attention in the literature. In this paper, we give a polyhedral analysis of the uncapacitated single allocation p-hub center problem (USApHCP). The analysis will be based on a radius formulation which currently yields the most efficient solution procedures. We show...

Functional hubs are brain regions that play a crucial role in facilitating communication among parallel, distributed brain networks. The developmental emergence and stability of hubs, however, is not well understood. The current study used measures of network topology drawn from graph theory to investigate the development of functional hubs in 99 participants, 10-20 years of age. We found that ...

This paper considers the discrete two-hub location problem. We need to choose two hubs from a set of nodes. The remaining nodes are to be connected to one of the two hubs which act as switching points for intemodal flows. A configuration which minimizes the total flow cost needs to be found. We show that the problem can be solved in polynomial dme when the hub locations are fixed. Since there a...

Performance test computations has been verified with a prototype. The HUB supporting ISO 11898-2 physical layer can operate at any baud rate, but in real systems the HUB can operate at baud rates up to 800kbps. In addition to the interfacespecific diagnostics features, HUB-based CAN-buses can ease systems designers by enabling star topology with improved tolerance against physical layer failure...

logistic regression models are frequently used in clinicalresearch and particularly for modeling disease status and patientsurvival. in practice, clinical studies have several limitationsfor instance, in the study of rare diseases or due ethical considerations, we can only have small sample sizes. in addition, the lack of suitable andadvanced measuring instruments lead to non-precise observatio...