Osteoporosis is a common musculoskeletal disease of the elderly population characterized by decreased bone mineral density and subsequent fractures. Bisphosphonates are a widely accepted drug therapy which act through inhibition of bone resorption and prevent fractures. However, in long-term use, atypical bisphosphonate induced fractures may occur, particularly involving the lower weight bearin...

Context: Primary hyperparathyroidism (PHPT) is commonly associated with reduced bone mineral density (BMD) presenting with osteoporosis, increasing the risk of bone fragility fractures in these patients. Bisphosphonates, due to their anti-resorptive action, are known to improve the BMD and reduce the risk of bone fragility fractures. Therefore, bisphosphonates are considered as an alternative t...

Reverse hammering is the method applied during nailing of transverse long bone fracture to decrease gap between ends ensure healing. This study aims asses effectiveness reverse on union in as well possible complications this method. Seventy six patients with (femur, tibia, & humerus) treated close reduction and internal fixation interlocking were enrolled a prospective conducted at departme...

BACKGROUND Risedronate sodium has recently been approved for the prevention and treatment of postmenopausal and corticosteroid-induced osteoporosis. METHODS Studies of risedronate were obtained from the MEDLINE database (1966 to the present) of references using risedronate, risedronic acid, osteoporosis, and human subject as keywords. Additional references were sought from the reference lists...

Bone loss and skeletal fragility in bone fracture are caused by an imbalance in bone remodeling. The current challenge in bone fracture healing is to promote osteoblastogenesis and bone formation. We aimed to explore the role of IL-20 in osteoblastogenesis, osteoblast differentiation and bone fracture. Serum IL-20 was significantly correlated with serum sclerostin in patients with bone fracture...

INTRODUCTION: Bisphosphonates (BPs) are commonly prescribed drugs for the treatment of osteoporosis, a condition of increased fracture risk. BPs inhibit bone resorption, and decrease bone turnover and bone loss. Long-term use of BPs may be associated with changes in the mechanical integrity of the bones of some patients. Odvina et al (2005) were the first to report on a group of nine patients w...

Introduction: It is well established that the MSCs reside among the stromal compartment of bone marrow and can differentiate into functional osteoblasts under specific conditions. The presence of primitive haematopoietic cells in adult peripheral blood has been recognized for three decades. However, there is a long-standing controversy as to whether MSCs can migrate through the circulation. A f...

Management of metastatic long bone fractures requires identification of the lesion and the use of sound fracture fixation principles to relieve pain and restore function. The treating surgeon must understand the principles of pathologic fracture fixation before initiating treatment. Because these fractures occur in the context of a progressive systemic disease, management typically involves a m...