نتایج جستجو برای: low density lipoprotein receptor ldl
تعداد نتایج: 2056114 فیلتر نتایج به سال:
fl-Migrating very-low-density lipoprotein (fl-VLDL) is a cholesteryl-ester-enriched lipoprotein which under normal conditions is rapidly cleared by parenchymal liver cells. In this study the characteristics of the interaction of,6-VLDL with rat parenchymal cells, Hep G2 cells and human parenchymal cells are evaluated. The binding of fl-VLDL to these cells follows saturation kinetics (Bmax respe...
The effects of the acidotropic agent, NH4Cl, on the recycling and turnover of low density lipoprotein (LDL) receptors were analyzed in human skin fibroblasts using ligand binding assays, [35S]methionine pulse-chase experiments, and electron microscopy. NH4Cl did not prevent receptor internalization but caused a marked redistribution of LDL receptors to intracellular sites (endosomes) that was c...
Lipid and lipoprotein responses to reduced dietary fat intake were investigated in relation to differences in distribution of low-density-lipoprotein (LDL) subclasses among 105 healthy men consuming high-fat (46% fat) and low-fat (24% fat) diets in random order for 6 wk each. With high-fat diets, 87 subjects had predominantly large, buoyant LDL (pattern A), whereas the remainder had primarily s...
background: serum lipids abnormalities have been observed in various forms of cancers including acute leukemia. investigators report decreased total cholesterol and hdl, and elevated triglyceride in leukemic patients. limited studies had been performed to discover the correlation between abnormal lipids profile and disease activity in leukemic patients in iran. this study was done to evaluate t...
background: the association between the lipid profiles level and the incidence and severity of coronary heart disease (chd) is very pronounced in epidemiological studies, and an inverse relation between physical fitness and the incidence of coronary heart disease has been observed in many studies. the aim of this study was to investigate the impact of a soccer match on lipid parameters of profe...
introduction: abnormal lipid profile causes maternal mortality and impairs fetal development. this study investigated the effect of ramadan fasting on plasma lipid profile in pregnant women. material and methods: this self-control, cohort study was performed in healthy volunteer fasted pregnant women. serum cholesterol, triglyceride (tg), low density lipoprotein (ldl), high density lipoprotein ...
Familial hypercholesterolaemia (FH) is a dominantly inherited condition that is due to a genetic defect in one of several genes that affect receptor-mediated uptake of low density lipoprotein (LDL) (see “Molecular Genetics” below). Affected individuals suffer metabolic and clinical features (Table 1) that include impaired uptake of plasma LDL cholesterol, resulting in high cholesterol levels an...
The incorporation of the lipid peroxidation product 4-hydroxynonenal into low-density lipoprotein (LDL) increases the negative charge of the particle, and decreases its affinity for the fibroblast LDL receptor. It is suggested that this modification may occur in vivo, and might promote atherogenesis.
The low-density lipoprotein receptor (LDLR) plays a pivotal role in clearing atherogenic circulating low-density lipoprotein (LDL) cholesterol. Here we show that the COMMD/CCDC22/CCDC93 (CCC) and the Wiskott-Aldrich syndrome protein and SCAR homologue (WASH) complexes are both crucial for endosomal sorting of LDLR and for its function. We find that patients with X-linked intellectual disability...
Hypercholesterolemia is involved in the development of atherosclerosis and a risk factor for coronary artery disease, stroke, peripheral vascular disease. This paper deals with mechanism hypercholesterolemic atherosclerosis. increases formation numerous atherogenic biomolecules including reactive oxygen species (ROS), proinflammatory cytokines [interleukin (IL)-1, IL-2, IL-6, IL-8, tumor necros...
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