Low-dose interferon-a (IFN-a) therapy is consistently effective in the treatment of hairy cell leukemia (HCL). In two cases of resistance to IFN-a administration, we diagnosed variant HCL, a form of HCL with intermediate features between typical HCL and B cell prolymphocytic leukemia. We tried to distinguish variant and typical hairy cells (HCs) by Northern blot analysis of the oncogenes expres...

Results are reported for a small study of 11 patients positive for HIV and with chronic active viral hepatitis. Low dose zidovudine/interferon alfa-2b combined treatment produced a general reduction in alanine aminotransferase activities and increased the CD4 lymphocyte count, hepatitis B e seroconversion, and the loss of HIV p24 antigen. The treatment was well tolerated and progression of HIV ...

scientific evidence regarding the efficacy and safety of the ldm approach in the treatment of psoriasis vulgaris, and positive preliminary data regarding the oral administration of low dose activated cytokines for vitiligo and atopic dermatitis treatment, support the ldm-based therapeutic approach for many dermatological diseases. ldm suggests the use of low-doses of activated biological molecu...

AIMS AND BACKGROUND Glioblastoma has a poor prognosis, with few therapeutic options if it recurs. We report a case in which we were able to inhibit the growth of a recurrent glioblastoma by weekly single-dose administration of interferon-beta. CASE REPORT A patient with recurrent glioblastoma after radiation and chemotherapy was treated with nimustine and interferon-beta. After 2 cycles of ni...

1 Antoniou KM, Ferdoutsis E, Bouros D. Interferons and their application in the diseases of the lung. Chest 2003; 123:209–216 2 Interferonin the idiopathic hypereosinophilic syndrome: consideration of five cases. Ann Hematol 1998; 77:161–164 3 Baratta L, Afeltra A, Delfino M, et al. Favorable response to high-dose interferonin idiopathic hypereosinophilic syndrome with restrictive cardiomyopath...

the frequency of chromosomal aberrations was studied in the peripheral blood lymphocytes of 65 radiology technologists crt) working at hospitals chronically exposed to x-rays. although film dosimetry did not show the maximal annual permitted dose in any of the examined subjects, cytogenetic analysis detected fairly high levels of chromosomal aberrations in r t compared to unexposed controls. th...

conclusions modern cts with the innovative technology of a built-in tin filter allow for significant reduction of radiation exposure in patients with suspected urolithiasis by optimizing the x - ray spectrum with image quality as high as in standard ct devices results ct examinations of a total of 143 patients were assessed. dlp of force was 56% and 55% lower in comparison to as+ and flash, (74...

Cardiac arrhythmias and syncope are rare consequence of therapy with pegylated interferon. We report a 55-year-old Egyptian woman who developed palpitation and syncopal attacks twice within 3 months after starting therapy with pegylated interferon alpha2b and ribavirin for the treatment of chronic hepatitis C virus. Hepatitis C virus-RNA was undetectable after 12 week. The electrocardiogram hol...