BACKGROUND The molecular underpinnings of hypoplastic left heart are poorly understood. Staged surgical palliation has dramatically improved survival, yet eventual failure of the systemic right ventricle necessitates cardiac transplantation in a subset of patients. We sought to identify genetic determinants of hypoplastic left heart with latent right ventricular dysfunction in individuals with ...

SETTING Tertiary adult congenital cardiac referral centre. DESIGN Retrospective cross sectional analysis. OBJECTIVES To report our 20 year experience with adult Fontan operations, and to compare late outcome in patients with single ventricle with definitive aortopulmonary or cavopulmonary shunt palliation. PATIENTS AND MAIN OUTCOME MEASURES Patients older than 18 years undergoing Fontan o...

heart failure is common in patients with chronic renal disease, either as a complication of renal failure or from shared risk factors, or is the major cause of death in patients on dialysis. at present, end stage renal disease (esrd) patients who have systolic heart failure are considered high-risk for surgery; and nephrologists and cardiologists are reluctant to refer these patients for kidney...

background: echocardiographic evaluations of the longitudinal axis of the left ventricular (lv) function have been used in the diagnosis and assessment of heart failure with normal ejection fraction (hfnef). the evaluation of the global and segmental peak systolic longitudinal strains (pslss) by two-dimensional speckle tracking echocardiography (ste) may correlate with conventional echocardiogr...

91 Since the first heart transplantation procedure was performed almost 50 years ago, heart transplantation has undergone a startling transformation from an experimental, high-risk intervention to being offered as standard of care for children and adults with heart failure refractory to medical and surgical therapy. The potential for heart transplantation to treat complex congenital heart disea...

1024x768 normal 0 false false false en-us x-none fa background : heart failure is a common health problem with poor prognosis. the gold standard for diagnosis is echocardiography but it is not always reachable, especially in emergency conditions. nt-pro-brain natriuretic peptide (nt-probnp) is a novel indicator for the diagnosis of heart failure and is being used in routine tests in emergency r...

OBJECTIVE To examine cardiopulmonary performance in 52 adult patients with a Fontan circulation. DESIGN Retrospective cohort study. Values of maximum oxygen uptake (VO(2)max), maximum heart rate (HRmax), forced vital capacity (FVC), and forced expiratory volume in one second (FEV(1)) were compared with predictive values for different age groups. Patients were further subdivided into those wit...

BACKGROUND Late complications after Fontan procedure may be due to the absence of pump and pulsatile pulmonary blood flow in this type of palliation. Our aim was to quantify the degree of pulsation by echocardiographic method in patients with extracardiac total cavopulmonary connection (ECTCPC) in comparison with biventricular circulation and few cases of pulsatile Fontan. METHODS In a case s...

The Fontan operation was first performed in 1968. Since then, this operation has been performed on thousands of patients worldwide. Results vary from very good for many decades to very bad with a pleiad of complications and early death. A good understanding of the physiology is necessary to further improve results. The Fontan connection creates a critical bottleneck with obligatory upstream con...