Twenty-nine patients with essential hypertension were studied while on their normal diets, on the 5th day of a high sodium diet (around 350 mmol/day) and on the 5th day of a low sodium diet (10 mmol/day). The fall in mean arterial pressure on changing from the high sodium to the low sodium diet was 9.0 +/- 1.6 mmHg and the rise in the plasma renin activity in the same period was 2.52 +/- 0.41 n...

We attempted to determine whether a diuretic-induced increase in renin secretion results in angiotensin II-mediated vasoconstriction which counteracts the antihypertensive action of diuretics. The angiotensui antagonist saralasin was administered to nine normal renin and five low renin essential hypertensives prior to and during stimulation of the renin-angiotendn system by 6 weeks of chronic d...

Literature data on the role of renin-angiotensin-aldosterone system in pathogenesis arterial hypertension and angiotensin-converting enzyme inhibitors treatment have been given.The is central element controlling body's water-salt balance blood pressure. The main effector link renin-angiotensin angiotensin II, which causes vasospasm, activates heart contraction, inhibits production bradykinin, p...

Plasma renin activity and renin substrate levels were measured during the development of cellophane perinephritis hypertension induced by either a bilateral renal wrap procedure or a wrap-nephrectomy procedure in 28 rabbits. Unoperated and unilaterally nephrectomized controls were also studied. Plasma renin concentration was derived from plasma renin activity and plasma renin substrate levels u...

Plasma renin activity and renin substrate levels were measured during the development of cellophane perinephritis hypertension induced by either a bilateral renal wrap procedure or a wrap-nephrectomy procedure in 28 rabbits. Unoperated and unilaterally nephrectomized controls were also studied. Plasma renin concentration was derived from plasma renin activity and plasma renin substrate levels u...