The significant morbidity and mortality associated with laterality disease almost always are attributed to complex congenital heart defects (CHDs), reflecting the extreme susceptibility of the developing heart to disturbances in the left-right (LR) body plan. To determine how LR positional information becomes ;translated' into anatomical asymmetry, left versus right side cardiomyocyte cell line...

CONTEXT The 2 fundamental subtypes of stroke are hemorrhagic stroke and ischemic stroke. Although neuroimaging is required to distinguish these subtypes, the diagnostic accuracy of bedside findings has not been systematically reviewed. OBJECTIVE To determine the accuracy of clinical examination in distinguishing hemorrhagic stroke from ischemic stroke. DATA SOURCES MEDLINE and EMBASE search...

RATIONALE Left-right (LR) asymmetry is ubiquitous in animal development. Cytoskeletal chirality was recently reported to specify LR asymmetry in embryogenesis, suggesting that LR asymmetry in tissue morphogenesis is coordinated by single- or multi-cell organizers. Thus, to organize LR asymmetry at multiscale levels of morphogenesis, cells with chirality must also be present in adequate numbers....

The space and time cost of LR parser generation is high. Robust and effective LR(1) parser generators are rare to find. This work employed the Knuth canonical algorithm, Pager’s practical general method, lane-tracing algorithm, and other relevant algorithms, implemented an efficient, practical and open-source parser generator Hyacc in ANSI C, which supports full LR(0)/LALR(1)/LR(1) and partial ...

Liver resection (LR) for the patients of hepatocellular carcinoma, often with chronic liver disease, have high risks of developing significant postoperative complications and multicentric metachronous repeat lesions with the need of repeat treatments. Reduction of surgery-induced parenchymal injury and destruction of the collateral blood/lymphatic flow, which leads to less post-operative ascite...

BACKGROUND Long-term recurrence (LR) is a tendency that re-occurs within 3 months after catheter ablation for atrial fibrillation (AF). Whether very early recurrence (VER) within 7 days of post ablation is a prognostic factor of LR or not is unclear. For this reason, present study sought to examine the relationship between VER and LR. METHODS In this prospective analysis 378 consecutive patie...

BACKGROUND Microcystin-LR, a cyclic heptapeptide, possesses the ability to inhibit the serine/threonine protein phosphatases PP1 and PP2A and, consequently, exhibits acute hepatocytotoxicity. Moreover, microcystin-LR induces cellular proliferation, resulting in tumor-promoting activity in hepatocytes. However, mechanisms that regulate the balance between cell death and proliferation after micro...

Not many receptors are as multifunctional as the 37kDa/67kDa laminin receptor (LRP/LR) [1,2]. Is LRP/LR the black sheep, the “bad boy”, the one who promotes cancer, prion disorders, Alzheimer’s disease, bacterial, viral and parasite infections? [1,2]. Indeed, LRP/LR, also known as LAMR, ribosomal protein SA (RPSA) or p40, acts as the receptor for the cellular and infectious prion proteins PrPc ...