Doxorubicin (DOX) is an anthracycline used widely for cancer chemotherapy. Its primary mode of action appears to be topoisomerase II inhibition, DNA cleavage, and free radical generation. However, in non-neuronal cells, DOX also inhibits the expression of dual-specificity phosphatases (also referred to as MAPK phosphatases) and thereby inhibits the dephosphorylation of extracellular signal-regu...

BACKGROUND Antiretroviral treatment (ART) coverage in Myanmar is well below average. This study describes retention and baseline predictors of prognosis from the largest ART program in the country. METHODS A cohort analysis of adult patients who initiated ART during 2003-2007 was conducted, with follow-up until the end of 2009. The primary outcome was attrition [death plus losses to follow-up...

BACKGROUND We report patient outcomes after antiretroviral therapy (ART) initiation in a network of HIV facilities in Haiti, including temporal trends and differences across clinics, during the expansion of HIV services in the country. METHODS We assessed outcomes at 12 months after ART initiation (baseline) using routinely collected data on adults (≥15 years) in 11 HIV facilities from July 2...

This paper makes two contributions towards determining some well-studied optimal constants in Fourier analysis of Boolean functions and high-dimensional geometry. 1. It has been known since 1994 [GL94] that every linear threshold function has squared Fourier mass at least 1/2 on its degree-0 and degree-1 coefficients. Denote the minimum such Fourier mass by W[LTF], where the minimum is taken ov...

Intermittent hypoxia (IH) can induce a persistent increase in neural drive to the respiratory muscles known as long-term facilitation (LTF). LTF of phrenic inspiratory activity is often studied in anesthetized animals after phrenicotomy (PhrX), with subsequent recordings being made from the proximal stump of the phrenic nerve. However, severing afferent and efferent axons in the phrenic nerve h...

Aim: The aim of this study was to determine the effect of different luting cements and accelerated artificial aging (AAA) in the fracture resistance of porcelain laminate veneers (PLVs). Materials and methods: A total of 80 disc-shaped specimens were prepared using computer-aided design/computer-aided milling technology from lithium disilicate glass-ceramic blocks. Specimens (0.5 mm thick, 10 m...

With the rapid development of global communication technology, problem scarce spectrum resources has become increasingly prominent. In order to alleviate frequency use, rationally use limited and improve utilization, prediction technology emerged. Through effective usage, number subsequent sensing processes can be slowed down, accuracy decisions increased response speed whole cognitive radio te...

Low-Tension-Foam (LTF) flooding is an emerging enhanced oil recovery technique for low-permeability carbonate reservoirs. Foam capacity closely related to the salinity environment (or, equivalently, phase behavior of oil/water/surfactant system). Therefore, interactions between microemulsion and foam components are primary importance in LTF process. In this study, system under equilibrium analy...

The MAPK isoforms ERK and p38 MAPK are believed to play opposing roles in long-term synaptic facilitation (LTF) induced by serotonin (5-HT) in Aplysia. To fully understand their roles, however, it is necessary to consider the dynamics of ERK and p38 MAPK activation. Previous studies determined that activation of ERK occurred ∼45 min after a 5-min pulse of 5-HT treatment. The dynamics of p38 MAP...