This study sought to compare the differences in target volumes and dose distributions to the targets and organs at risk (OARs) between a four-dimensional computed tomography (4DCT)-based respiratory-gated intensity-modulated radiation therapy (IMRT) plan (PlanEOE) and a three-dimensional CT (3DCT)-based IMRT plan (Plan3D) in patients with non-small-cell lung cancer (NSCLC). For 17 patients with...

PURPOSE Hypofractionated partial breast irradiation (HPBI) involves treatment to the breast tumor using high doses per fraction. Recent advances in MRI-Linac solutions have potential in being applied to HPBI due to gains in the soft tissue contrast of MRI; however, there are potentially deleterious effects of the magnetic field on the dose distribution. The purpose of this work is to determine ...

The application of simultaneous integrated boost-intensity modulated radiotherapy (SIB-IMRT) in pediatric and adolescent nasopharyngeal carcinoma (NPC) is underevaluated. This study aimed to evaluate long-term outcome and late toxicities in pediatric and adolescent NPC after SIB-IMRT combined with chemotherapy. Thirty-four patients (aged 8-20 years) with histologically proven, non-disseminated ...

BACKGROUND AND PURPOSES To compare the dosimetry for the left-sided breast cancer treatment using five different radiotherapy techniques. MATERIALS AND METHODS Twenty patients with left sided breast cancer were treated with conservative surgery followed by radiotherapy. They were planned using five different radiotherapy techniques, including: 1) conventional tangential wedge-based fields (TW...

This study aimed to compare the post-modified radical mastectomy radiotherapy (PMRMRT) for left-sided breast cancer utilizing 3-dimensional conformal radiotherapy with field-in-field technique (3DCRT-FinF), 5-field intensity-modulated radiation therapy (5F-IMRT) and 2- partial arc volumetric modulated arc therapy (2P-VMAT). We created the 3 different PMRMRT plans for each of the ten consecutive...

Beam Angle Optimization for Automated Coplanar IMRT Lung Plans by Kathryn Hedrick Medical Physics Graduate Program Duke University Date:_______________________ Approved: ___________________________ Q. Jackie Wu, Supervisor ___________________________ Jing Cai ___________________________ Anuj Kapadia An abstract of a thesis submitted in partial fulfillment of the requirements for the degree of M...

Background: The design of intensity modulated radiation therapy (IMRT) plans is difficult and time-consuming. The retrieval of similar IMRT plans from the IMRT plan dataset can effectively improve the quality and efficiency of IMRT plans and automate the design of IMRT planning. However, the large IMRT plans datasets will bring inefficient retrieval result. Materials and Methods: An intensity-m...

Intensity-modulated radiation therapy (IMRT) provides the protection of the normal organs and a precise treatment plan through its optimization process. However, the final dose-volume histogram (DVH) obtained by this technique differs from the optimal DVH, owing to optimization convergence errors. Herein, intermediate dose calculation was applied to IMRT plans during the optimization process to...

To investigate the clinical characteristics associated with the risk of developing secondary primary tumors (SPTs) in patients with nasopharyngeal carcinoma (NPC) who underwent intensity-modulated radiotherapy (IMRT).Data from 527 patients with biopsy-proven nonmetastatic NPC who were treated with IMRT between January 2007 and December 2011 were analyzed retrospectively. The cumulative incidenc...

BACKGROUND To evaluate the association between the clinical, dosimetric factors and severe acute radiation pneumonitis (SARP) in patients with locally advanced non-small cell lung cancer (LANSCLC) treated with concurrent chemotherapy and intensity-modulated radiotherapy (IMRT). METHODS We analyzed 94 LANSCLC patients treated with concurrent chemotherapy and IMRT between May 2005 and September...