We have used double-stranded RNA (dsRNA)-mediated RNA interference (RNAi) to disrupt neuronal nitric oxide (NO) synthase (nNOS) gene function in the snail Lymnaea stagnalis and have detected a specific behavioral phenotype. The injection of whole animals with synthetic dsRNA molecules targeted to the nNOS-encoding mRNA reduces feeding behavior in vivo and fictive feeding in vitro and interferes...

Background The effects of chronic exercise training on myocardial contractility and ,B-adrenergic signal transduction in hearts with left ventricular dysfunction have not been determined. Methods and Results Fourteen-week-old cardiomyopathic BIO 53.58 and normal F1B Syrian hamsters underwent 10 weeks of treadmill training and were compared with 24-weekold BIO 53.58 and F1B untrained controls. L...

Methods have been developedto isolatemitochondriafrom small amounts of normal and leukemic human lymphocytes obtained from small volumes of circulating blood. Mitochondrial respiratory functions were measured by polarographic tech niques, and active calcium uptake was measured by a spectro photometric procedure utilizing the calcium-sensitive dye mu rexide. The results indicate that the rates o...

We prove localization at the bottom of the spectrum for a random Schrödinger operator in the continuum with a single-site potential probability distribution supported by a Cantor set of zero Lebesgue measure. This distribution is too singular to be treated by the usual methods. In particular, an “a priori” Wegner estimate is not available. To prove the result we perform a multiscale analysis fo...

Let 2[n] denote the Boolean lattice of order n, that is, the poset of subsets of {1, . . . , n} ordered by inclusion. Extending our previous work on a question of Füredi, we show that for any c > 1, there exist functions e(n) ∼ √n/2 and f(n) ∼ c √ n log n and an integer N (depending only on c) such that for all n > N , there is a chain decomposition of the Boolean lattice 2[n] into ( n ⌊n/2⌋ ) ...

Successful treatment of melanoma and lymphoma may result from the induction of specific antitumor immunity. Dendritic cells (DCs) are pow erful antigen-presenting cells and show a remarkable capacity to stimulate antigen-specific T-cell responses. Administration of FLT3 ligand (FL) results in a reversible accumulation of functionally active DCs in both lymphoid and nonlymphoid tissues. Therefor...

Endoscopic features of intestinal lympho− ma usually comprise infiltration of the intestinal wall: the affected segment is ri− gid, reddish, fragile, and often bleeds spontaneously. Irregular nodular pattern and multiple ulcers with scaring may also be found [1± 3]. We report two cases of macroscopically visible neo−vasculari− zation as a newly recognized endoscopic feature of intestinal lympho...

We begin with an introduction to hypergraphs, which gives a taste of different representations of hypergraphs, linear hypergraphs, and Turán-type problems, including existence of Turán densities and classification of zero Turán densities. Thereafter we delve deeper into some of the classical theorems of hypergraph theory, including various theorems on intersecting families such as Sperner’s The...

Rabbit anti-mouse lymphoid-eell serum (ALS) could either facilitate or inhibit the outgrowth of antigenic sarcoma and lymphoma cell grafts in syngencic hosts, depending on the tumorhost combination. In certain cases, the treatment acted in parallel with the response of the preimmunized host leading to a more efficient rejection. In other cases the opposite was true: host response was counteract...

Continuous lymphoblastoid cell cultures were established from marmoset (Saguinus sp.), squirrel (SaimirÃ-sciureus), owl (Aotus trivirgatus), and cebus (Cebus apella) monkeys after their peripheral lymphocytes were cultured with lethally, X-irradiated cells carrying Epstein-Barr virus (EBV). Simian lymphocytes were also transformed after exposure to infectious, cell-free EBV derived from some si...