To investigate the in vivo cellular tropism of human T cell leukemia virus type II (HTLV-II), subpopulations of fresh peripheral blood mononuclear cells from infected individuals were isolated and analyzed by polymerase chain reaction for the presence of provirus. In eight of nine patients, HTLV-II was detected exclusively in the CD8 + T lymphocyte population. In the remaining patient, provirus...

Murine intestinal intraepithelial lymphocytes (IEL) from unprimed thymus-bearing and athymic nude mice were characterized according to the expression of murine lymphocyte antigenic markers and cytotoxic activity. The majority of IEL from thymus-bearing mice were Lyt-2+, L3T4- lymphocytes, over half of which did not express Thy-1 surface antigens. Nude IEL and spleen cells were void of Thy-1+ ce...

Cells that participate in immune complex-induced production of leukocyte migration inhibitory factor (LIF) activity can be concentrated in a population making up 2-4% of human peripheral blood lymphocytes in which greater than 90% of the cells are active in a single cell antibody-dependent cellular cytotoxicity assay. When so concentrated, such killer (K) cell preparations are as efficient in p...

Recent experiments (11-13) have shown that antigen-specific, CD8+, CD4- T lymphocytes can be induced to proliferate and become killer cells in the absence of a second population of "helper" CD8-, CD4+ cells. We have studied early events in the activation of CD4+ and CD8+ T cell subsets in the primary mixed leukocyte reaction. Dendritic cells are a major if not essential accessory cell for the a...

To investigate the in vivo cellular tropism of human T cell leukemia virus type II (HTLV-II), subpopulations of fresh peripheral blood mononuclear cells from infected individuals were isolated and analyzed by polymerase chain reaction for the presence of provirus. In eight of nine patients, HTLV-II was detected exclusively in the CD8+ T lymphocyte population. In the remaining patient, provirus ...

The immunologic cell types of the Indian fruit bat, P. giganteus, were characterized on the basis of cell surface Ig markers. Rabbit anti-rat IgM and IgG demonstrated IgM or IgG bearing cells in the nylon wool adherent lymphocyte population, thereby suggesting their equivalence to the B cells of recently evolved mammals including man. Relative proportion of these Ig+ surface bearing cells was a...

Nuclear transcription factor B (NF-B) regulates innate and adaptive immunity functions mediates inflammatory responses by activating proinflammatory cytokine gene transcription. TNF inhibitors block the NF-B signaling pathway, thus reducing activity. The aim of study was to evaluate informativity NF-kB determination in lymphocyte populations children with bowel disease (IBD) psoriasis assess ef...

Spontaneous abortion is the most common complication of pregnancy. Several lines of evidence indicate that immunologic effector cells may play a role in the pathogenesis of idiopathic repetitive abortions. Leukocytes form a substantial proportion of stromal cells in decidua and the endometrial granulated lymphocytes (eGL) is the predominant decidual leukocyte population in the first trimester o...

Plasma cells are terminally differentiated B lymphocytes that provide protective immunity through the continuous secretion of antibodies. Antibody-secreting cells develop in secondary lymphoid tissue following antigen stimulation and may enter a short-lived plasmacell population that resideprimarily in thenonlymphoid areaof the spleenor lymph nodes, or instead may migrate to the bone marrow whe...