The primary cutaneous CD30-positive (CD30+) T-cell lymphoproliferative disorders are a group of largely indolent diseases that manifest as nodules or tumors of the skin. The European Organisation for Research and Treatment of Cancer (EORTC) has developed a modification of the World Health Organization (WHO) lymphoma classification system that specifically categorizes these entities. According t...

Lymphoproliferative Disorder (LPD) is a complication of Methotrexate (MTX) therapy. Several cases Methotrexate-Associated (MTX-LPD) have been reported. However, pulmonary lesions in MTX-LPD are rare. Image findings show various patterns. Pneumocystis pneumonia and interstitial pneumonia, which complex courses, reported MTX-treated patients with lung diseases other than MTX-LPD. Furthermore, the...

INTRODUCTION — Acquired deficiency of C1 inhibitor (C1-INH), also called acquired angioedema (AAE), is a rare syndrome of recurrent episodes of angioedema, without urticaria, which is associated with B cell lymphoproliferative disorders in some patients [1,2]. Angioedema typically affects the skin or mucosal tissues of the upper respiratory and gastrointestinal tracts. The swelling is self-limi...

Nodular regenerative hyperplasia (NRH) of the liver is often associated with rheumatologic or lymphoproliferative disorders and a cause of portal hypertension in some patients. We report the case of a 71-year-old patient with celiac disease and unexplained portal hypertension. Biopsy of the liver revealed NRH as the underlying cause. The patient did not suffer from an autoimmune, rheumatologic ...

Waldenstrom macroglobulinemia (WM) is a B-cell lymphoproliferative disorder associated with bone marrow involvement of lymphoplasmacytic lymphoma (LPL) and an IgM monoclonal gammopathy. Generally B-lymphocytes in LPL do not express CD5 that is important for differential diagnosis of B-cell lymphoproliferative disorders. In WM, various renal diseases and type I cryoglobulinemia are well describe...

Castleman’s disease is a rare non-neoplastic lymphoproliferative disorder of unknown origin. It classified into unicentric or multicentric based on its anatomical distribution. Multicentric can be subdivided according to the presence human herpesvirus-8 (HHV-8) infection. has incidence, and HHV-8-positive even rarer. There are several types natural course for this disease, rapidly progressing t...