Buccal delivery involves the administration of the desired drug through the buccal mucosal membrane lining of the oral cavity.The objective of this article is to review buccal drug delivery by discussing the structure and environment of the oral mucosa and highlighting the mechanisms of drug permeation and methodology in evaluating buccal formulations. This review also highlights a brief descri...

One of the disadvantages of conventional milling tools is to produce a large amount of heat in cutting zone and so making the tool warmer. As a result, the tool would be worn and its life time would be reduced. Therefore, in long time machining, it is essential to change inserts and tools, continiously. A milling tool with self rotary cutting inserts was designed and manufactured that enables i...

In this paper, experimentally derived correlations of heat transfer and pressure drop are used in a Pareto based Multi-Objective Optimization (MOO) approach to find the best possible combinations of heat transfer and pressure drop of TiO2-water nanofluid flow in tubes fitted with multiple twisted tape inserts in different arrangement. In this study there are four independent design variables: t...

  Ceramic materials due to their high compressive strength and hardness have been one of prime candidates in armor design in particular when high level threads (impact velocity above 600m/s) are involved. The aim of this work is to investigate ballistic impact resistance potential for a target plate with novel ceramic inserts as against ceramic tiles. Two size 98% alumina (AL2O3) base ceramic i...

In this study we lyophilized three types of live attenuated polioviruses (Sabin vaccine strains) and evaluated the lyophilized vaccine viruses' heat stability. The virus titers were measured after heating at 37 and 45 and then compared with the titers of conventional liquid vaccine viruses similarly treated. The results showed that lyophilization, while slightly reducing vaccine virus titers,...

objective: microleakage in the gingival floor of class ii composite restorations can compromise the marginal adaptation of the filling material to the cavity edges. the aim of this study was to evaluate the effect of light conducting cylindrical inserts in decreasing the microleakage of the gingival floor in cavities 1mm below the cej. materials and methods: eighty maxillary first molars were r...

The combination of the ionic liquid co-lyophilized lipase and microwave irradiation was used to improve enzyme performance in enantioselective esterification of α-lipoic acid. Effects of various reaction conditions on enzyme activity and enantioselectivity were investigated. Under optimal condition, the highest enantioselectivity (E = 41.2) was observed with a high enzyme activity (178.1 μmol/h...

Bioadhesion can be defined as the process by which a natural or a synthetic polymer can adhere to a biological substrate. When the biological substrate is a mucosal layer then the phenomena is known as mucoadhesion. The substrate possessing bioadhesive property can help in devising a delivery system capable of delivering a bioactive agent for a prolonged period of time at a specific delivery si...

Intranasal route is one of the most attractive routes for distributing drugs to systemic circulation. Liposomes are used as biocompatible carriers to improve delivery properties across nasal mucosa. The objective of the present study was to formulate acyclovir liposomes and partition into poly-N-vinyl-2-pyrrolidone. Entrapment efficiency showed that multilamellar and unilamellar liposomes were ...

Background: Low density lipoprotein (LDL) of egg yolk has been successfully used for stallion and bull semen cryopreservation. However, there is limited information to clarify the effect of LDL or lyophilized LDL on ram semen quality. On the other hand, during semen collection, dilution and cryopreservation we need to protect the spermatozoa from lipid peroxidation. Clove bud has polyphenolic c...