methylprednisolone (mp) has been widely used as a standard therapeutic agent for the treatment of spinal cord injury (sci). because of its controversial useful effects, the combination of mp and other pharmacological agents to enhance neuroprotective effects is desirable. magnesium sulfate (mgso4) has been shown to have neuroprotective and antihyperalgesic effects. in the present study, we soug...

Delayed cerebral ischemia (DCI) is a feared complication and an important cause of poor outcome after aneurysmal subarachnoid hemorrhage (SAH). In the current study, Wong and colleagues performed a systematic review and meta-analysis of randomized controlled trials that investigated the efficacy of magnesium sulfate in patients with aneurysmal SAH. Outcome measures were DCI, cerebral infarction...

CONTEXT Prenatal magnesium sulfate may reduce the risk of cerebral palsy or death in very preterm infants. OBJECTIVE To determine the effectiveness of magnesium sulfate given for neuroprotection to women at risk of preterm birth before 30 weeks' gestation in preventing pediatric mortality and cerebral palsy. DESIGN, SETTING, AND PATIENTS Randomized controlled trial at 16 tertiary hospitals ...

PURPOSE Dexmedetomidine and magnesium sulfate have been used in anesthesia as adjuvant to provide hemodynamic stability and anesthetic agents sparing effect. We compared these effects of dexmedetomidine and magnesium sulfate in spine surgeries. METHODS Ninety patients were randomly assigned to three groups. Group D received dexmedetomidine loading dose 1 µg/kg over a period of 15 minutes and ...

1 Sachett DL, Haynes RB, Guyatt GH, et al. Clinical epidemiology: a basic science for clinical medicine, 2nd ed. Boston: Little, Brown and Co, 1991Appraisal card 2 Wood KL, Fletcher S. Long-term outcome after intravenous magnesium sulfate in suspected acute myocardial infarction: the second Leicester intravenous magnesium intervention trail (LIM¬ IT-2). Lancet 2:343:816-19 3 ISIS-4: A randomize...

BACKGROUND Martian regolith (unconsolidated surface material) is a potential medium for plant growth in bioregenerative life support systems during manned missions on Mars. However, hydrated magnesium sulfate mineral levels in the regolith of Mars can reach as high as 10 wt%, and would be expected to be highly inhibitory to plant growth. METHODOLOGY AND PRINCIPAL FINDINGS Disabling ion transp...

objective: the aim of this study was to evaluate the effect of zinc and magnesium supplementation on glycemic control and serum insulin in type 2 diabetic patients. materials and methods: in this randomized clinical trial 70 diabetic patients who referred to yazd diabetes center were selected. subjects received 500 mg/day magnesium oxide or 100 mg/day zinc sulfate randomly for 8 weeks. at the s...

conclusions both remifentanil and magnesium had favorable outcomes in preventing hr and map elevation after tracheal extubation. however, remifentanil was associated with more rapid regaining of consciousness and reversal of muscular relaxation. results the hr was significantly lower, immediately after extubation and 3, 5, and 10 minutes after extubation, in both magnesium and remifentanil grou...

IMPORTANCE Antenatal magnesium sulfate given to pregnant women at imminent risk of very preterm delivery reduces the risk of cerebral palsy in early childhood, although its effects into school age have not been reported from randomized trials. OBJECTIVE To determine the association between exposure to antenatal magnesium sulfate and neurological, cognitive, academic, and behavioral outcomes a...