OBJECTIVE Beta-thalassemia major is an autosomal recessive disease causing severe and hemolytic anemia, which begins about 2-6 months after birth. Iron overload, which arises from recurrent transfusion and ineffective erythropoiesis, can enhance oxidative stress in thalassemic patients. The aim of this study was to evaluate the serum total antioxidant capacity of patients with ß-Thalassemia maj...

OBJECTIVE This cross-sectional study determined the CD4, CD8 counts and serum immunoglobulins in transfusion dependent b - thalassemic patients, and correlated them with anti-HIV, anti-HCV and HBsAg status, number of transfusions, iron overload and splenectomy. METHODS Patients with acute or chronic diseases (except HIV, Hepatitis B and C), on immunosuppressive drugs or vaccinated within one ...

objective: β-thalassemia is caused by absence or reduction of β-globin chain synthesis. one of the effective therapeutic methods for this disease can be gene therapy by viral vectors. the capacity of lentiviral vectors is approximately 8 kb, we designed a 6 kb construct containing mini lcr and β-globin gene instead of lcr region. the aim of this study is to make a recombinant lentiviruses conta...

background: preterm birth is a major health problem that leads to infant morbidity and mortality. the main goal of this study was to find the relationship between social determinants of health and preterm delivery. methods: a prospective longitudinal cohort study was carried out on 500 pregnant women in their 24th to 28th gestational weeks in 2012. the pregnant women filled out a self-report qu...

abstract background: thalassemias are the most common inherited blood disorders caused by some mutations which can reduce the synthesis of globin chains. iron overload and its organ deposition are responsible for functional abnormalities and tissue injury in patients who affected by β-thalassemia major. the aim of this case-control study was evaluation of hematological parameters, oxidative str...

background: coronary artery disease (cad) is the major cause of mortality and morbidity worldwide. the aim of this study was to explore the effect of resveratrol (res) on canonical β-catenin/wnt and forkhead box o (foxo) pathways in cad patients.method: we performed this study on 10 metabolic syndrome patients with three-vessel cad and 10 sex-aged matched healthy subjects. the effects of res on...

The effects of Cu and Mg contents on the thermal stability 6XXX-series aluminum alloys was investigated using tensile testing, scanning electron microscopy, backscattered diffraction transmission microscopy. Results showed that improved with increasing contents, precipitate most important factor for stability. In alloy without Cu, strengthening precipitates are mainly β″ phases. After heat hold...

γ-aminobutiric acid (gaba), the major inhibitory neurotransmitter in the central nervous system is activated by the antispastic and muscle relaxant agent, baclofen, which is a lipophilic derivative of gaba. because of its biological and pharmacological importance, there are several reports in the literature about the synthesis of baclofen since 1962. in this study baclofen was easily synthesize...

Peptides have shown Promising effect as pharmaceutics with the potential to treat a widevariety of diseases. Peptides are mostly synthesized by biological technology or chemicalmethods. Solution phasepeptide synthesis (SPS) and solid phase peptide synthesis (SPPS) aretwo major chemical techniques for peptidesproduction.In this research, the synthesis ofdipeptde(β-alanine-L-histidine)wasexamined...

Results The screened records included 49 221 pregnant women, and 4503 husbands of the pregnant women showed positive on the screening test. Of the at-risk couples, there were 198 for α-thal (4.4%) and 83 for β-thal (1.8%), respectively. Genetic counseling was offered to all at-risk couples and a successful prenatal diagnosis was performed for 269 out of 281 (95.7%) for αor β-thal major, with th...