background : the application of ventilation systems in industries and workplaces is with the aim of improving environmental conditions for employees. the lack of appropriate ventilation system components design and control methods result in the production of sound and vibration in most components. the purpose of this study was to determine the role of the pad isolator in controlling vibration a...

Endothelin-1 binding to endothelin A receptors (ETA) elicits profibrogenic, proinflammatory, and proliferative effects that can promote a wide variety of diseases. Although ETA antagonists are approved for the treatment of pulmonary hypertension, their clinical utility in several other diseases has been limited by fluid retention. ETA blocker-induced fluid retention could be due to inhibition o...

BACKGROUND Bile duct injury is a severe complication of laparoscopic cholecystectomy and many reports focus on this topic, especially regarding the long-term success of repair of these injuries. There is some concern, however, as to whether concomitant vascular injuries can jeopardize reconstruction of a bile duct injury following laparoscopic cholecystectomy. METHODS A review of the current ...

The anatomy of the thoracic duct varies considerably, rendering it prone to disruption during thoracic surgery. Chylothorax complicates up to 0.5% of all intrathoracic procedures, its morbidity requiring the surgeon's vigilance throughout the entire course of the patient's illness. The natural history of chylothorax includes cardiopulmonary dysfunction, immunosuppression, nutritional and electr...

Women exposed to diethylstilbestrol (DES) in utero develop abnormalities, including cervicovaginal adenosis that can lead to cancer. We report that transient disruption of developmental signals by DES permanently changes expression of p63, thereby altering the developmental fate of Müllerian duct epithelium. The cell fate of Müllerian epithelium to be columnar (uterine) or squamous (cervicovagi...

Biliary atresia is an obstructive cholangiopathy of infancy that progresses to end-stage cirrhosis. Although the pathogenesis of the disease is not completely understood, previous reports link TNFα to apoptosis of the bile duct epithelium in the presence of IFNγ. Here, we investigate if TNFα signaling regulates pathogenic mechanisms of biliary atresia. First, we quantified the expression of TNF...

Large-eddy simulation (LES) using an unstructured overset numerical method is performed to study the flow around a ducted marine propeller for highly unsteady off-design condition called crashback. Known as one of most challenging states analyse, rotates in reverse direction yield negative thrust while vehicle still forward motion. The LES results David Taylor Model Basin 4381 with neutrally lo...