Prematurely-born infants are exposed to multiple invasive procedures while in the intensive care unit. Newborn rats and humans have similar behavioral responses to noxious stimulation. Previous studies have shown that early noxious stimuli may alter dentate gyrus neurogenesis and the behavioral repertoire of adult rats. We evaluated the late effects of noxious stimulation administered during di...

introduction: indomethacin increases generation of mitochondrial reactive oxygen species (ros) which have a crucial role in the indomethacin-induced gastric ulcer. coenzyme q10 has an antioxidant activity on mitochondria and cell membranes and protects lipids from oxidation and is essential for stabilizing biological membranes. superoxide dismutase (sod) acts as one of the defense mechanisms ag...

Objective. To determine the most effective method of segmental bone allograft fixation during — prosthesis composite based on searching x-ray density tissue at experimental animals. Methods. The work was performed 28 laboratory white male rats (age 5 months, weight 350–400 g), which were divided into 2 groups, 14 animals in each group. All underwent allograft-prosthesis hip replacement: after t...

OBJECTIVES Although schizophrenia affects both human genders, there are gender-dependent differences with respect to age of onset, clinical characteristics, course and prognosis of the disease. METHODS To investigate sex-dependent differences in motor coordination and activity as well as in cognitive and social behavior, we repeatedly tested female (n = 14) and male (n = 12) Fisher rats (post...

triazine derivatives are small synthetic peptides with no apparent toxicity and high target specificity in central nervous system. hippocampal tissue is the most vulnerable area in the alzheimer’s disease (ad). the aim of this study was to investigate the neuroprotective effect of triazine in ad induced by intra-cerebro-ventricular (i.c.v.) administration of streptozotocine (stz). male wistar, ...

A bioassay for possible carcinogenicity of technical-grade allyl chloride (3-chloropropene) was conducted using Osborne-Mendel rats and B6C3F1 mice. At initiation of the study the rats were approximately 6 weeks old and the mice approximately 5 weeks old. Allyl chloride in corn oil was administered by gavage to two groups of each species for 5 days a week for 78 weeks, followed by observation p...

toxic effects of trace elements upon the hypothalamic- pituitarytesticular axis and sex hormones have been reported in recent years. it is generally considered that cdcl2 poisoning causes histopathological changes in the testicles of male rats. little attention had been drawn to the possible toxic effects of cdcl2 on the ovary and female sex hormones. the purpose of the present study was to det...

A bioassay of technical-grade 1,2-dichloroethane for possible carcinogenicity was conducted using Osborne-Mendel rats and B6C3F1 mice. 1,2-Dichloroethane in corn oil was administered by gavage, at either of two dosages, to groups of 50 male and 50 female animals of each species. The 78-week period of chemical administration was followed by an observation period of 32 weeks for the low dose rats...

In the current study, 14 male Holstein calves aged 11-12 months were used from Usak Cattle Breeders Association Research Farm. this study lasting for 60 days, cattle and divided into 2 groups as control treatment. The feeding method, which is routinely applied in enterprise, was to group. addition same ration, 250 gr/head/day crushed anise seed powder feed additive poured on of treatment group ...