Background: P53 tumor suppressor gene mutation is one of the most common genetic alterations in human malignancies. The mutated from of the gene is stable and can be detected with immunohistochemistry methods. There is much controversy about the expression rate of this gene in malignant melanoma. Objective: To determine the frequency of the P53 antigen expression by sex, age, type and thickness...

Malignant melanoma of the oral cavity is a rare tumor that occurs due to uncontrolled growth melanocytes found in basal layer mucous membranes. Majority melanomas occur maxilla, especially on keratinizing mucosa palate and gingiva. Clinically have different types like pigmented nodular type, macular mixed non-pigmented type type. Here, we present case report 57 year old female patient with muco...

UNLABELLED Clear cell sarcoma is a rare cancer primarily of tendons, fascia, and aponeuroses that can be difficult to discern from primary cutaneous malignant melanoma. The two cancers share several histological markers, with most cases of both cancers staining positively for S-100, HMB-45, and melanin. Primary therapy of both cancers involves wide local excision, but while systemic therapy has...

Melanoma has been reported a contemporary malignant cancer. Here, anti-cancer effects of sea cucumber extract (SCE) have been examined on melanoma cells and compared with dacarbazine. MTT assay and morphological analysis were performed to evaluate cytotoxic effects of methanolic SCE Also, several methods were exerted to detect cell dying by SCE and dacarbazine. The MTT assay showed that B16F10 ...

Malignant melanoma of the sphenoid sinus is a very rare disease, and only 6 cases have previously been reported. The present case involved a 74-year-old woman who was examined for visual disturbance of the left eye. Computed tomography revealed a soft tissue shadow, but only mucosal hypertrophy was found on opening the sphenoid sinus under general anesthesia. One month postoperatively, visual d...

Melanomas are malignant neoplasms originating from melanocytes. They reported in birds.  In this  case, macroscopic and microscopic (the histopathologic and IHC) findings supported a final diagnosis  of cutaneous malignant melanoma in a mallard duck (Anas platyrhynchos). A female mallard duck  (Anas platyrhynchos) was observed with a mass on the ventral portion of the neck. Th...

Amelanotic melanoma is met only in 28% of cases with malignant melanoma. The incidence of brain metastases in patients with malignant melanoma ranges from 643% of cases. Brain metastases are frequently associated with malignant melanoma after the intratumorale hemorrhage. We choose to present the case of 58-years-old men with a frontal brain metastasis of amelanotic malignant melanoma.

We present a case of malignant melanoma with a rhabdoid phenotype in a 44-year-old female with a quite unique and aggressive clinical course. Rhabdoid features are defined by characteristics such as sheets or solid trabeculae of neoplastic cells with large, vesicular, round to bean-shaped nuclei, prominent centrally located nucleoli, and abundant eccentric cytoplasm. Although various histologic...

Activating mutations in the BRAF serine/threonine kinase are found in >70% of human melanomas, of which >90% are BRAF. We sought to investigate the role of the BRAF allele in malignant melanoma. We here report that suppression of BRAF expression by RNA interference in cultured human melanoma cells inhibits the mitogen-activated protein kinase cascade, causes growth arrest, and promotes apoptosi...