Drynaria fortunei (KUNZE) J. SM. (DFE) is one of the most frequently used traditional Chinese medicines prescribed for the treatment of osteoporosis in China. The present study was designed to investigate the osteoprotective constituents from Drynaria fortunei. The 60% ethanol extract of the rhizome of D. fortunei (DFE) was chromatographed on a D-101 macroporous resin column (psi 25x150 cm); th...

iron overload is a serious clinical condition which can be largely prevented by the use of iron-specific chelating agents. in this study, the synthesis and determination of partition coefficients (kpart) of a range of n-alkyl hydroxypyridinones, as orally active iron chelators, are described. synthesis of n-aryl hydroxypyridinones was achieved via a single step synthetic pathway. in this method...

recently, it has been shown that a number of hydroxypyridinones such as 1,2-dimethyl-3-hydroxypyridin-4-one (l1) are useful for the treatment of iron overload in place of desferrioxamine in thalassaemic patients. in this study, the intestinal absorption (i.a.) of l1 and one of its analogues namely 2-methy-3-hydroxypyridin-4-one (l2), which possesses a higher partition coefficient (kpart) than l...

Aconitum brachypodum Diels. (AB.) is a plant of L. The dried roots AB have analgesic and anti-inflammatory activity. However, the processing required to reduce toxicity before use because its high toxicity. Studies on toxicity, pharmacodynamics, chemical composition processed PAB. are still lacking at present. In this study, changes PAB were determined by ultra-performance liquid chromatography...

When considering the idea of sustainable development, as desirable future of our civilization, we tend to focus attention on biomass in general and particular plants and crops, as renewable resources of food and energy. Currently celebrated International Year of Chemistry (IYC 2011) should, in our opinion, provide an inspiration for some wider perspective, in particular for rational exploitatio...