نتایج جستجو برای: mania
تعداد نتایج: 3443 فیلتر نتایج به سال:
When analysing and reporting data from long-term drug trials in bipolar disorder, it has become the standard to break down the outcome into the prevention of mania and the prevention of depression. However, as illustrated by a theoretical example, this approach may confer a potential analysis bias. The point is that when mania or depression, whatever appears first, is considered an endpoint, th...
OBJECTIVE Few double-blind trials have compared longer-term efficacy and safety of medications for bipolar disorder. The authors report a 47-week comparison of olanzapine and divalproex. METHOD This 47-week, randomized, double-blind study compared flexibly dosed olanzapine (5-20 mg/day) to divalproex (500-2500 mg/day) for manic or mixed episodes of bipolar disorder (N=251). The only other psy...
BACKGROUND Athanasios Koukopoulos proposed the primacy of mania hypothesis (PoM) in a 2006 book chapter and later, in two peer-reviewed papers with Nassir Ghaemi and other collaborators. This hypothesis supports that in bipolar disorder, mania leads to depression, while depression does not lead to mania. OBJECTIVE To identify evidence in literature that supports or falsifies this hypothesis. ...
Studies from the USA suggest that rates of pediatric bipolar disorder have increased since the mid-90s, but no study outside the USA has been published on the rates of pediatric bipolar disorder. Further, it is unclear whether an increase in rates reflects a true increase in the illness or more diagnostic attention. Using nationwide registers of all inpatients and outpatients contacts to all ps...
Anticonvulsants, including valproate and carbamazepine, have established efficacy in the treatment of mania. The anticonvulsant, lamotrigine. has been reported to have antimanic and antidepressant efficacy, and mood-stabilising effects in case reports and preliminary open trials. The efficacy and tolerability of lamotrigine has been compared with olanzapine and lithium in a randomised, prospect...
Noradrenergic and GABA systems may be involved in mania, but there is little information about relationships between the function of these systems and response to specific antimanic treatments. We investigated relationships between indices of catecholamine or GABA system function, pretreatment mania severity and antimanic response to divalproex, lithium, or placebo. Plasma GABA and urinary excr...
Bipolar disorder contributes substantially to the global burden of disease. Both sleep disturbance and life events predict symptoms of mania, although the underlying mechanisms associated with these relationships have been difficult to elucidate. In this report, we explore the relationships among life events, sleep disturbance, and mania in an effort to provide support for the hypothesis that s...
Mania in HIV infected individuals is an uncommon clinical presentation. It can, however, complicate any stage of the HIV infection. We herewith report a set of three case reports of patients with HIV infection who developed manic episodes. The cases highlight some aspects of the plausible relationship between HIV infection and mania. HIV infection could be revealed by manic episode, it could it...
Despite a growing body of empirical data describing the discriminant and longitudinal validity of mania in older children, little research has been conducted investigating the presence of mania symptoms in preschool-aged children. This report describes three cases of preschool children (ages 3.6 to 5.2) who presented to a subspecialty mental health clinic manifesting age-adjusted mania-like sym...
Background: The identification of differences in seasonality and chronotype may provide useful information regarding unipolar mania as a distinct entity. Therefore, the present study was planned to compare seasonality and chronotype in patients with unipolar mania and bipolar disorder. Method: A cross-sectional study included 60 euthymic outpatients, 30 affected by bipolar affective disorder (b...
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