Streptomyces , the largest genus in Actinobacteria, has been known as a chemically prolific bacterial group producing pharmaceutically important small molecules. Various endeavors have made to discover novel secondary metabolites from strains inhabiting diverse environmental niches. In our course of collecting biologically active molecules, marine-derived sp. V17-9 was isolated seagrass collect...

BACKGROUND Antitumor compounds PM100117 and PM100118 are glycosylated polyketides derived from the marine actinobacteria Streptomyces caniferus GUA-06-05-006A. The organization and characterization of the PM100117/18 biosynthesis gene cluster has been recently reported. RESULTS Based on the preceding information and new genetic engineering data, we have outlined the pathway by which PM100117/...

The last two decades had witnessed extensive investigation on bacterial degradation of carbazole, an N-heterocyclic aromatic hydrocarbon. Specifically, previous studies have reported the primary importance of angular dioxygenation, a novel type of oxygenation reaction, which facilitates mineralization of carbazole to intermediates of the TCA cycle. Proteobacteria and Actinobacteria are the pred...

Host-associated bacterial communities are potentially critical components of marine microbial diversity, yet our understanding of bacterial distribution on living surfaces lags behind that for planktonic communities. We used 16S rRNA gene library analysis to compare within-host (alpha) and between-host (beta) diversity among bacterial communities on 3 co-occurring marine eukaryotes from tempera...

The HCV infection is a major cause of human hepatitis worldwide and the World Health Organization estimates that virus chronically infected about 170 million people [10-11]. These patients usually do not show clinical symptoms until they evolve into serious cases [12]. This represents a major public health problem worldwide, because patients with chronic HCV infection present a high risk of dev...

Actinobacterial classification was originally based largely on morphological observation; it is not adequate in itself to differentiate between many genera, because some are so sim‐ ilar morphologically, but differ from their diagnostic chemical composition. In search of reliable classification methods reflecting phylogenetic relationships, at least to the genus level, it has been demonstrated ...

In situ amendments are a promising approach to enhance removal of metal contaminants from diverse environments including soil, groundwater and sediments. Apatite and chitin were selected and tested for copper, chromium, and zinc metal removal in marine sediment samples. Microbiological, molecular biological and chemical analyses were applied to investigate the role of these amendments in metal ...

In organisms other than higher plants, family 19 chitinase was first discovered in Streptomyces griseus HUT6037, and later, the general occurrence of this enzyme in Streptomyces species was demonstrated. In the present study, the distribution of family 19 chitinases in the class Actinobacteria and the phylogenetic relationship of Actinobacteria family 19 chitinases with family 19 chitinases of ...