BACKGROUND Currently the rate-limiting step for mass spectrometric analysis of drugs in biological samples is sample preparation. Many gas chromatography/mass spectrometry (GC/MS) methods are specific for a certain class of compounds, requiring extraction and/or derivatization before analysis. The purpose of this study was to develop a broad spectrum liquid chromatography/mass spectrometry (LC/...

The coupling of gas and liquid chromatography with mass spectrometry is addressed from the historical point of view. This paper discusses the more important coupling interfaces developed for GC/MS and LC/MS, including the moving belt interface, direct liquid introduction interfaces, thermospray and atmospheric pressure ionization interfaces such as atmospheric pressure chemical ionization and e...

Knowledge of the identity and relative amounts of the volatile substances released by plants is of great importance to several fields of basic and applied research in biology, chemistry and may other disciplines. Obtaining this knowledge requires overcoming many analytical challenges posed by these complex mixtures, because they normally present large variations in component amounts, chemical s...

A simple method for tracing carbon fixation and lipid synthesis in microalgae was developed using a combination of solid-phase extraction (SPE) and negative ion chemical ionisation gas chromatography mass spectrometry (NCI-GC-MS). NCI-GC-MS is an extremely sensitive technique that can produce an unfragmented molecular ion making this technique particularly useful for stable isotope enrichment s...

We examined the decomposition behavior of 1-acyl-substituted derivatives d-lysergic acid diethylamide (LSD), such as 1-cyclopropanecarbonyl LSD (1cP-LSD), 1-acetyl (ALD-52), and 1-propionyl (1P-LSD) through gas chromatography/mass spectrometry (GC/MS). It was reported previously that in methanol, 1cP-LSD completely decomposed into during GC/MS. found remained undecomposed GC/MS, extent varied b...

Ethylene vinyl acetate (EVA), commonly used to encapsulate photovoltaic (PV) modules, deteriorates on prolonged exposure sunlight. In this work, fresh and deteriorated EVA samples prepared by UV irradiation (500 W m−2) over different periods (0–168 h) are characterized conventional elemental analysis, microscopic observations, Fourier transform infrared (FT-IR) spectroscopy, thermogravimetry. T...

A wide range of estrogenic contaminants has been detected in the aquatic environment. Among these, natural and synthetic steroid estrogens, typically present in municipal sewage-treatment plant (STP) effluents, are the most potent. In this study a new GC-MS method has been developed for direct analysis of five major steroid estrogens (estrone, 17beta-estradiol, 17alpha-ethinylestradiol, dienest...

Effective deoxygenation in catalytic fast pyrolysis (CFP) is crucial for bio-oil stabilization and its successful commercialization. Herein, we utilize a new analytical platform that couples gas chromatography (GC) to dopant-assisted atmospheric pressure chemical ionization (dAPCI) time-of-flight mass spectrometry (TOF MS) to evaluate catalytic deoxygenation of cellulose pyrolysis. Soft ionizat...

A method for the analysis of glufosinate ammonium (GLUF) and its metabolite 3-methylphosphinicopropionic acid (MPPA) in human serum by gas chromatography-mass spectrometry (GC-MS) was developed. Employing a mixed-mode cartridge with both anion exchange action and weak nonpolar interaction, we extracted GLUF and MPPA from the serum and carried out GC-MS analysis of their tert-butyldimethylsilyl ...

Gas chromatography mass spectrometry (GC-MS) and headspace gas chromatography mass spectrometry (HS/GC-MS) were used to study metabolites produced by Lactococcus lactis subsp. cremoris MG1363 grown at a temperature of 30 °C with and without agitation at 150 rpm, and at 37 °C without agitation. It was observed that L. lactis produced more organic acids under agitation. Primary alcohols, aldehyde...