UNLABELLED To present a review of cross-sectional and longitudinal studies that investigate the relationship between the hormones Dehydroepiandrosterone (DHEA) and Dehydroepiandrosterone sulfate (DHEA-S) and cognition. METHODS The cognition items included in this review were global cognitive function, memory, attention, executive function, intelligence, perception and visuospatial ability. A ...

background: pregnancy and accelerated fetal growth always are related with major metabolic changes and body fat redistribution and adiponectin is one of principle adipocyte hormones, so studying adiponectin changes during pregnancy may reveal some hidden parts of fetal metabolism. the aim of this study was to assess adiponectin and leptin levels in umbili cal cord and maternal serum, their rela...

It has been suggested that dehydroepiandrosterone (DHEA) and its sulfate ester, dehydroepiandrosterone sulfate (DHEAS), have a protec tive effect against breast cancer. In our investigation, DHEAS levels were measured in plasma obtained and frozen in 1972-1974 from 534 women aged 50-79 yr. This group, which has been followed for 15 yr, included 21 incident cases of breast cancer, 20 cases with ...

The general aging sequence in tissues of healthy human beings is proposed to be: capillary endothelial cell damage --> arteriosclerosis --> decreased blood flow --> metabolic dysregulation --> secondary tissue damage. Molecular O2 is an obligatory substrate for the successive syntheses of 17alpha-OH pregnenolone and dehydroepiandrosterone (DHEA) by cytochrome P450c17 in the zona reticularis of ...

Adrenarche is a developmental event involving differentiation of the adrenal gland and production of adrenal androgens, and has been hypothesized to play a role in the extension of the preadolescent phase of human ontogeny. It remains unclear whether any nonhuman primate species shows a similar suite of endocrine, biochemical, and morphological changes as are encompassed by human adrenarche. He...

Background: World population is rapidly aging, and the elderly are most at risk of cognitive impairment. Dehydroepiandrosterone (DHEA) and DHEA-Sulfate (DHEAS) have an essential effect on neuroprotection and might effectively improve cognition and memory. Objectives: This study aimed to investigate the relationship between the level of DHEA and memory function in the elderly. Materials & Meth...

THE AIM OF THE STUDY The aim of the study was to determine menopause-related changes in serum levels of main proinflammatory and anti-inflammatory cytokines. MATERIAL AND METHODS The study included 175 women, who were divided into 5 study groups (group 1 - fertile women; group 2 - pre- and perimenopausal women; group 3 - postmenopausal women; group 4 - surgically induced menopausal women; gro...