The main objective of this review is to emphasize the role and importance of the careful mathematical/computational modeling of signaling networks for the understanding of aberrant signaling in cancer and for the development of targeted therapies.

Terrorism is generally understood to be the use of threat or extra normal violence to gain ideological reasons and personal benefit. In this paper, a mathematical modelling of terrorism with military strategies and rehabilitation of terrorists was constructed. The model is developed to control the spread of terrorist ideologies in the society and suitable to describe terrorist group. The popula...

Interactions between cancer cells and their microenvironment are crucial for promoting tumor growth and invasiveness. In the tumor adaptive landscape model, hypoxic and acidic microenvironmental conditions reduce the fitness of cancer cells and significantly restrict their proliferation. This selects for enhanced motility as cancer cells may evolve an invasive phenotype if the consequent cell m...

In this paper, a new five-parameter lifetime and reliability distribution named “the exponentiated Uniform-Pareto distribution (EU-PD),” has been suggested that it has a bathtub-shaped and inverse bathtub-shape for modeling lifetime data. This distribution has applications in economics, actuarial modelling, reliability modeling, lifetime and biological sciences. Firstly, the mathematical and st...

The ability of cancer cells to break out of tissue compartments and invade locally gives solid tumours a defining deadly characteristic. One of the first steps of invasion is the remodelling of the surrounding tissue or extracellular matrix (ECM) and a major part of this process is the over-expression of proteolytic enzymes, such as the urokinase-type plasminogen activator (uPA) and matrix meta...