Background: The C2 domain is a Ca2 sensor that drives the first step in the activation of conventional PKC isozymes. Results:Hydrophobic interactions drive membrane association and electrostatic interactions drive membrane retention of the C2 domain. Conclusion: The amplitude and location of conventional PKC signaling is controlled by residues in the C2 domain. Significance: Point mutations in ...

The AML/CBFalpha runt transcription factors are key regulators of hematopoietic and bone tissue-specific gene expression. These factors contain a 31-amino acid nuclear matrix targeting signal that supports association with the nuclear matrix. We determined that the AML/CBFalpha factors must bind to the nuclear matrix to exert control of transcription. Fusing the nuclear matrix targeting signal ...

BN fiber coatings in SiC-SiC composites are vulnerable to oxidation and volatilization at elevated temperature the presence of water vapor. These processes lead coating recession composite interior with fronts starting from matrix cracks proceeding axially along fibers. In some operational domains, main effect is de-couple fibers matrix, precluding load transfer that would otherwise occur throu...

Normal epithelial cells undergo apoptosis if integrinmediated matrix contacts are lost, in a process termed 'anoikis'. Anoikis prevents shed epithelial cells from colonizing elsewhere, and is thus essential for maintaining appropriate tissue organisation. Aberrant oncogenes or tumor suppressor genes can cause resistance to anoikis, thereby contributing substantially to malignancy. Apoptosis is ...

Collaborative filtering is an effective recommendation approach in which the preference of a user on an item is predicted based on the preferences of other users with similar interests. A big challenge in using collaborative filtering methods is the data sparsity problem which often arises because each user typically only rates very few items and hence the rating matrix is extremely sparse. In ...

Collective matrix factorization has achieved a remarkable success in document classification in the literature of transfer learning. However, the learned latent factors still suffer from the divergence between different domains and thus are usually not discriminative for an appropriate assignment of category labels. Based on these observations, we impose a discriminative regression model over t...

The macromolecular structure of type X collagen in the matrices of primary cultures of chick hypertrophic chondrocytes was initially investigated using immunoelectron microscopy. Type X collagen was observed to assemble into a matlike structure with-in the matrix elaborated by hypertrophic chondrocytes. The process of self assembly was investigated at the molecular level using purified chick ty...

This paper presents a Coq formalization of linear algebra over elementary divisor rings, that is, rings where every matrix is equivalent to a matrix in Smith normal form. The main results are the formalization that these rings support essential operations of linear algebra, the classification theorem of finitely presented modules over such rings and the uniqueness of the Smith normal form up to...

Domains within fluid membranes grow by the aggregation of molecules which diffuse laterally within the membrane matrix. A simple theoretical model is introduced which predicts that a flat or weakly curved domain becomes unstable at a certain limiting size and then undergoes a budding or invagination process. This instability is driven by the competition between the bending energy of the domain ...