The seed maturation program is repressed during germination and seedling development so that embryonic genes are not expressed in vegetative organs. Here, we describe a regulator that represses the expression of embryonic seed maturation genes in vegetative tissues. ASIL1 (for Arabidopsis 6b-interacting protein 1-like 1) was isolated by its interaction with the Arabidopsis thaliana 2S3 promoter...

Shewanella are renowned for their ability to respire on a wide range of electron acceptors, which has been partially accredited to the presence of a large number of the c-type cytochromes. In the model species S. oneidensis MR-1, at least 41 genes encode c-type cytochromes that are predicted to be intact, thereby likely functional. Previously, in-frame deletion mutants for 36 of these genes wer...

Members of the Wnt gene family, encoding secreted cystein-rich glycoproteins, have been isolated from a variety of organisms. They serve as important developmental signaling molecules and have been implicated to play crucial roles in such diverse processes as cancer, organogenesis and pattern formation. Experiments by Zakany and Duboule, and Rudnicki and Brown have suggested a role for Wnt mole...

Regulatory T cells (Tregs) participate in the negative regulation of inflammatory reactions by suppressing effector cells. In a number autoimmune disorders, suppressive function and/or Tregs is compromised. The lack active functioning can be restored with adoptive transfer expanded ex vivo autologous Tregs. our study, we traced differentiation and maturation CD4+CD25+FoxP3+CD127low over 7 days ...

Seed development represents a unique transition state in the life cycle of higher plants, providing the physical link between parenta1 and progeny sporophytic generations. During embrye genesis, the root and shoot apical meristems are specified, thus establishing the basic architecture of the seedling, and differentiation of vegetative tissue and organ systems occurs. Maturation events prepare ...

Seed development represents a unique transition state in the life cycle of higher plants, providing the physical link between parenta1 and progeny sporophytic generations. During embrye genesis, the root and shoot apical meristems are specified, thus establishing the basic architecture of the seedling, and differentiation of vegetative tissue and organ systems occurs. Maturation events prepare ...

Seed development represents a unique transition state in the life cycle of higher plants, providing the physical link between parenta1 and progeny sporophytic generations. During embrye genesis, the root and shoot apical meristems are specified, thus establishing the basic architecture of the seedling, and differentiation of vegetative tissue and organ systems occurs. Maturation events prepare ...

Phagocytosis and autophagy are two lysosome-mediated cellular degradation pathways designed to eliminate extracellular and intracellular constituents, respectively. Recent studies suggest that these two processes intersect. Several autophagy proteins have been shown to participate in clearance of apoptotic cells, but whether and how the autophagy pathway is involved is unclear. Here we showed t...

The Saccharomyces cerevisiae RPS0A/B genes encode proteins of the 40S ribosomal subunit that are required for the maturation of 18S rRNA. We show here that the RPS0 genes interact genetically with TOM1. TOM1 encodes a member of the hect-domain-containing E3 ubiquitin-protein ligase family that is required for growth at elevated temperatures. Mutant alleles of the RPS0 and TOM1 genes have synerg...

Stearoyl-CoA desaturase (SCD) catalyzes the rate-limiting step in the cellular synthesis of monounsaturated fatty acids, mainly oleate (18:1) and palmitoleate (16:1), which are the major monounsaturated fatty acids of membrane phospholipids, cholesteryl esters, waxes, and triglycerides. The mouse expresses three well-characterized SCD genes (SCD1, 2, and 3). SCD1 is the main isoform expressed i...