A myeloid cell line, designated P1-21 . was established from the peripheral blood of a patient with acute promyelocyt.c leukemia. The P1-21 cell line grew in single-cell suspension, with a doubling time of 48-64 hr. and consisted of promyelocytes with fine immature nuclei and prominent azurophilic granules in the cytoplasm. P1-21 cells were positive for peroxidase, naphthol AS-D chloroacetate e...

background: most studies on anabolic-androgenic steroids abuse have been done in adult rats, but few data are available to immature. objective: this study was conducted to assay the effect of nandrolone decanoate (nd) on the testis and testosterone concentration in male immature rats compare with mature ones in short and long time. materials and methods: 40 mature rats were divided into 4 group...

Recurrent abnormalities of the short arm of chromosome 9, including translocations and interstitial deletions, have been reported in both leukemia and lymphoma. The pathologic consequences of these abnormalities remain unknown. The cyclin-dependent kinase 4 inhibitor (CDKN2j gene. which maps to 9p21, has been implicated by the finding of a high frequency of biallelic deletions in leukemic cell ...

Hairy cell leukemia is a rare lymphoid neoplasm arising from mature B-lymphocytes. Clinically, the disease presents with splenomegaly and abdominal discomfort, frequent infections, fatigue and bleeding because of related cytopenias. Bone marrow biopsy is essential for diagnosis. Below we describe a case of a 70-year-old African-American male who presented to our hematology clinic complaining of...

BACKGROUND The subtype distribution of lymphoid neoplasms in Southwest China was analyzed according to WHO classifications. This study aims to analyze subtype distribution of lymphomas in southwest China. METHODS Lymphoid neoplasms diagnosed within 9 years in a single institution in Southwest China were analyzed according to the WHO classification. RESULTS From January 2000 to December 2008...

The significance of immunophenotyping is growing day by day. Itprovides basic information in regard to classification and prognosisof acute leukemia which helps the management of patients. Thisstudy was conducted to Identify CD markers in leukemic patientsadmitted to Tabriz, in northwestern Iran. Immunophenotyping of 60patients with acute leukemia was determined. Patients with acutemyelogenous ...

The analysis of leukocyte differentiation has been greatly enhanced by developments in three areas of methodology: Firstly by the establishment of relatively stable permanent hematopoietic cell lines of a variety of origin, secondly by the development of numerous specific polyclonal and monoclonal heterologous antibodies to various leukocyte antigens, and thirdly by the introduction of many fun...

Human T cell leukemia virus type 1 (HTLV-1) is the etiological agent of adult T cell leukemia/lymphoma (ATLL) and several inflammatory diseases. Tax, the protein encoded by HTLV-1, may be responsible for the development of the diseases caused by this virus. To investigate the pathogenic role of Tax, several transgenic mouse strains expressing Tax have been developed in recent years. These mice ...