Drug resistance is a serious challenge in cancer treatment and can be acquired through multiple mechanisms. These molecular changes may introduce varied extents of resistance to different therapies and need to be characterized for optimal therapy choice. A recently discovered small molecule, ethyl-2-amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate) (CXL017), revea...

Triple-negative breast cancer is the most aggressive breast cancer subtype. The aim of our study was to investigate the functional role of both miR-101 and MCL-1 in the sensitivity of human triple-negative breast cancer (TNBC) to paclitaxel. We found that the expression of miR-101 was strongly decreased in triple-negative breast cancer tissues and cell lines. The expression of miR-101 was not a...

Emodin is an active component of a traditional Chinese and Japanese medicine isolated from the root and rhizomes of Rheum palmatum L. Here, we show that emodin significantly induces cytotoxicity in the human myeloma cells through the elimination of myeloid cell leukemia 1 (Mcl-1). Emodin inhibited interleukin-6-induced activation of Janus-activated kinase 2 (JAK2) and phosphorylation of signal ...

AIMS To determine whether immunohistochemistry applied to paraffin wax embedded biopsy tissue can be used to distinguish between B-small lymphocytic lymphoma (B-SLL) and mantle cell lymphoma (MCL). METHODS Formalin fixed, paraffin wax embedded tissue blocks of 12 cases of B-SLL and 12 cases of MCL were retrieved from the files of the Department of Pathology, Southampton University Hospitals T...

Melanoma is a particularly aggressive tumor type that exhibits a high level of resistance to apoptosis. The serine/threonine kinase B-RAF is mutated in 50% to 70% of melanomas and protects melanoma cells from anoikis, a form of apoptosis induced by lack of adhesion or adhesion to an inappropriate matrix. Mutant B-RAF down-regulates two BH3-only proapoptotic proteins, Bim(EL) and Bad. BH3-only p...

©2003 British Editorial Society of Bone and Joint Surgery doi:10.1302/0301-620X.85B7.14405 $2.00 e studied the stabilising effect of prosthetic replacement of the radial head and repair of the medial collateral ligament (MCL) after excision of the radial head and section of the MCL in five cadaver elbows. Division of the MCL increased valgus angulation (mean 3.9 ± 1.5 ̊) and internal rotatory la...

Deregulation of microRNA (miR)-193b has been revealed to be associated with the proliferation of liver cells. However, the interaction between miR-193b and their targets inducing liver cancer remains largely unknown. The aim of the present study was to investigate the hypothesis that miR-193b affects the proliferation of liver cancer cells. In the present study, the overall survival of patients...

This paper investigates the effect of KOH and NaOH on C-S-H structure solubility. Both have a similar effect, they increase pH values silicon concentrations, decrease calcium concentrations. At higher alkali hydroxide more portlandite precipitates, while amorphous silica dissolves. increases Ca/SiC-S-H at low Ca/Sitarget but lowers maximum from 1.5 to 1.2 in 1 M KOH/NaOH. The amount alkalis bou...

To explore the feasible treatment alternatives for organic contaminant, especially organic arsenic species in the landfill gas (LFG) condensate, a variety of treatment approaches were examined and evaluated in this study. Biological degradation, conventional and advanced oxidation, and physical absorption showed limited effectiveness to convert the methylated arsenic to inorganic arsenic. Rever...

Elbow instability often results in chronic overuse injuries, especially with overhead throwing in athletes. Initial management of medial collateral ligament (MCL) injuries often is conservative, but surgery may be required. In several studies, nearly half of throwing athletes with MCL injuries who were treated conservatively were able to return to their previous level of competition. Surgical t...