Abstract Major Depressive Disorder (MDD) and Generalized Anxiety (GAD) are highly debilitating often co-morbid disorders. The disorders exhibit partly overlapping dysregulations on the behavioral neurofunctional level. determination of disorder-specific may therefore promote neuro-mechanistic diagnostic specificity. In order to determine alterations in domain emotion-cognition interactions pres...

BACKGROUND Family studies provide a useful approach to exploring the continuities and discontinuities between major depressive disorder (MDD) in children and adolescents and MDD in adults. We report a family study of MDD in a large community sample of adolescents. METHODS Probands included 268 adolescents with a history of MDD, 110 adolescents with a history of nonmood disorders but no histor...

Context: Model-Driven Development (MDD) is a paradigm that prescribes building conceptual models that abstractly represent the system and generating code from these models through transformation rules. The literature is rifely represent the system and generating code from these models through transformation rules. The literature is rife with claims about the benefits of MDD, but they are hardly...

Assessing neural commonalities and differences among depression, anxiety and their comorbidity is critical in developing a more integrative clinical neuroscience and in evaluating currently debated categorical vs dimensional approaches to psychiatric classification. Therefore, in this study, we sought to identify patterns of anomalous neural responding to criticism and praise that are specific ...

BACKGROUND Most previous neuroimaging studies have focused on the structural and functional abnormalities of local brain regions in major depressive disorder (MDD). Moreover, the exactly topological organization of networks underlying MDD remains unclear. This study examined the aberrant global and regional topological patterns of the brain white matter networks in MDD patients. METHODS The d...

Detection of minimal disseminated disease (MDD) at diagnosis correlates with relapse risk in children with anaplastic lymphoma kinase (ALK)-positive anaplastic large-cell lymphoma (ALCL). We investigated whether minimal residual disease (MRD) positivity by qualitative reverse-transcriptase polymerase chain reaction (RT-PCR) for Nucleophosmin (NPM)-ALK during treatment identifies patients at the...

Disjunctive scheduling is the problem of scheduling activities that must not overlap in time. Constraint-based techniques, such as edge finding and not-first/not-last rules, have been a key element in successfully tackling large and complex disjunctive scheduling problems in recent years. In this work we investigate new propagation methods based on limited-width Multivalued Decision Diagrams (M...

MDP is a workshop about the interrelation of modeldriven development (MDD) and development processes. The workshop provides a forum for researchers and practitioners to exchange experiences on the questions how processes need to adapt or can be adapted when model-driven techniques are applied. We argue that the interrelation between MDD and development processes can be crucial for the success o...

BACKGROUND Dual processing models of psychopathology emphasize the relevance of differentiating between deliberative self-evaluative processes (explicit self-esteem; ESE) and automatically-elicited affective self-associations (implicit self-esteem; ISE). It has been proposed that both low ESE and ISE would be involved in major depressive disorder (MDD) and anxiety disorders (AD). Further, it ha...

BACKGROUND The close association between generalized anxiety disorder (GAD) and major depressive disorder (MDD) prompts questions about how to characterize them in future diagnostic systems. We tested whether risk factors for MDD and GAD are similar or different. METHOD The representative 1972-73 Dunedin birth cohort of 1037 males and females was followed to age 32 with 96% retention. Adult G...