BACKGROUND & OBJECTIVES Uniform therapy for all leprosy patients will simplify leprosy treatment. In this context, we evaluated six-month multidrug therapy (MDT) currently recommended for multibacillary (MB) patients as uniform MDT (U-MDT) in a single-arm open trial under programme conditions. Primary objective was to determine efficacy to prevent five-year cumulative five per cent relapse. Sec...

A 30-year-old male presented with a huge skin lesion on his back of 7 months duration. He had taken paucibacillary multi-drug therapy (PB MDT) privately for the last 2 months. Swelling and redness had developed 1 month after starting the treatment. He had also developed a small satellite lesion near the lower end of this large lesion. There was no history of fever. Examination revealed a very l...

Until the early 1 980s, dapsone monotherapy administered to known patients was used for control of leprosy. Dapsone was usually administered in a dosage of 100 mg daily for a minimum of 5 years to patients with paucibacillary (PB) leprosy, and for life to patients with multibacillary (MB) leprosy. Because it was a weakly bactericidal and slowly acting drug, dapsone monotherapy led to poor patie...

BACKGROUND Major lower limb amputations result in a significant sense of loss, psychological stress, and decrease in function and overall quality of life for the amputee. The holistic, patient-centered prosthetic rehabilitation of an amputee requires input from a team of dedicated health professionals from different disciplines commonly referred to as a multidisciplinary team (MDT). MDT rehabil...

Maggot debridement therapy (MDT) is a safe, effective, and controlled method ofhealing of chronic wounds by debridement and disinfection. In this therapy live, sterile maggots of green bottle fly, Lucilia (Phaenicia) sericata are used, as they prefernecrotic tissues over healthy for feeding. Since centuries, MDT is used in humanbeings to treat chronic wounds. Lately, MDT came out as a potent me...

The Gravity Field and Steady-State Ocean Circulation Explorer (GOCE) and satellite altimetry can provide very detailed and accurate estimates of the mean dynamic topography (MDT) and geostrophic currents in China’s marginal seas, such as, the newest high-resolution GOCE gravity field model GOCONS-GCF-2-TIM-R4 and the new Centre National d’Etudes Spatiales mean sea surface model MSS_CNES_CLS_11 ...

This paper is concerned with how to improve the training of higher-level military officers, given that the conditions for learning in “conventional” exercises (with a high degree of realism and complexity) are suboptimal. From other applications (e.g., business and public management) we know that a key feature of effective decision training is high exercise frequency. Another requirement is for...

The microencapsulation of cells has shown promise as a therapeutic vehicle for the treatment of a wide variety of diseases. While alginate microcapsules provide an ideal cell encapsulation material, polycations coatings are commonly employed to enhance stability and impart permselectivity. In this study, functionalized hyperbranched alginate and dendrimer polymers were used to generate discreet...

Individual-level cognitive remediation therapy (CRT) has been shown to be effective for cognitive improvement and social function amelioration. Here, we aimed to test the efficacy of group-based CRT in Chinese subjects with schizophrenia. One-hundred and four inpatients were randomly assigned to either 40 sessions of small-group CRT therapy or therapeutic contact-matched Musical and Dancing The...