To predict volume of distribution at steady-state (V(ss)), empirical (e.g., allometry) and mechanistic (using physicochemical property data and plasma protein binding) methods have been used. None of these approaches has been able to predict V(ss) accurately for the total compliment of a wide range of drugs. Therefore, alternative approaches would be of value. This study evaluates the utility o...

A decision support system (DSS) for systematic control of priority pollutants (PP) sources, based on economic activities and production (release) processes in urban catchments was recently developed. One of the crucial functionalities of the DSS is evaluation of source control measures, which is based on mathematical models, used for simulating the fate of the PPs in urban catchments under diff...

This paper presents an overview of how mechanistic knowledge of organism-environment interactions, including biomechanical interactions of heat, mass and momentum transfer, can be integrated into basic theoretical population biology through mechanistic functional responses that quantitatively describe how organisms respond to their physical environment. Integrating such functional responses int...

This paper deals with the representation of the family in Japanese TV commercials. Based on empirical research conducted in 2004 and 2005, it argues that Japanese commercials tend to depict the family and its members in highly stereotypical ways. Mothers are almost always shown doing some kind of housework, at times supported by their daughters, preparing for their future role as a mother and w...

Objectives Information technology involves a risk of privacy violation in providing easy access to confidential information,such as personal information and medical information through the Internet. In this study, we investigated medical information security to gain a better understanding of trends in research related to medical information security. Methods We researched papers published on ...

Data warehouses (DWs) can become inconsistent when some dimensional constraints are not satisfied by the dimension instances. In this paper, we present preliminary results about the effects of the violation of partitioning constraints in homogeneous dimension instances over aggregation queries, and in particular over the summarizability property (SUMM) of the DWs. We are interested in finding w...

We consider the classical statistical learning/regression problem, when the value of a real random variable Y is to be predicted based on the observation of another random variableX . Given a class of functions F and a sample of independent copies of (X,Y ), one needs to choose a function f̂ from F such that f̂(X) approximates Y as well as possible, in the mean-squared sense. We introduce a new p...

Let F be a class of measurable functions f :S 7→ [0,1] defined on a probability space (S,A, P ). Given a sample (X1, . . . ,Xn) of i.i.d. random variables taking values in S with common distribution P , let Pn denote the empirical measure based on (X1, . . . ,Xn). We study an empirical risk minimization problem Pnf →min, f ∈ F . Given a solution f̂n of this problem, the goal is to obtain very ge...