Microneurography was used in healthy human subjects to record action potentials from unmyelinated nerve fibers (C units) in cutaneous fascicles of the peroneal nerve. Activity-dependent slowing (n = 96) and transcutaneous electrical thresholds (n = 67) were determined. Eight units were sympathetic efferents according to their responses to sympathetic reflex provocations. Mechano-heat-responsive...

ATP-dependent chromatin remodeling enzymes (CRE) are bio-molecular motors in eukaryotic cells. These are driven by a chemical fuel, namely, adenosine triphosphate (ATP). CREs actively participate in many cellular processes that require accessibility of specific segments of DNA which are packaged as chromatin. The basic unit of chromatin is a nucleosome where 146 bp ∼ 50 nm of a double stranded ...

Dynamic chemical devices involve morphological or constitutional modifications in molecular or supramolecular systems, induced by internal or external physical or chemical triggers. Reversible changes in shape result in molecular motions and define motional dynamic devices presenting mechanical-like actions of various types. Suitably designed polyheterocyclic strands such as compounds 1-5 wrap ...

Background: Developing effective methods for the synthesis of bio-compatible and non-toxic nanoparticles is the main goal of nanotechnology. In the most chemical methods, a chemical reducing agent is used to reduce metal ions. But, in chemical methods, the stability of nanoparticles is controversial and synthesis in large sizes is much more difficult. Moreover, there is an incr...

Polycystic kidney disease is characterized by cardiovascular irregularities, including hypertension. Dopamine, a circulating hormone, is implicated in essential hypertension in humans and animal models. Vascular endothelial primary cilia are known to function as mechano-sensory organelles. Although both primary cilia and dopamine receptors play important roles in vascular hypertension, their re...

a one-pot synthesis of (s)-(-)-propranolol is reported. zn(no3)2/(+)-tartaric acid catalyzed enantioselective synthesis of (s)-(-)-propranolol via kinetic resolution of key intermediate ?-naphthyl glycidyl ether with high optical and chemical yield.

nanocrystalline hydroxyapatite was precipitated from calcium hydroxide and phosphoric acid. effects of precipitation temperature and different calcium to phosphate ratios (ca/p) on the obtained powders were investigated. characteriza-tion of the powders was performed using xrd and ftir spectra, scanning electron microscopy, and transmission electron microscopy. increase in precipitation tempera...