The ETS domain transcription factor Elk-1 stimulates expression of immediate early genes (IEGs) in response to mitogens. These events require phosphorylation of Elk-1 by extracellular signal-regulated kinase (ERK) and phosphorylation-dependent interaction of Elk-1 with co-activators, including histone acetyltransferases and the Mediator complex. Elk-1 also recruits ERK to the promoters of its t...

OBJECTIVES This study explored treatment mediators among caregivers of older adults who did not benefit from expressive writing in a recently published randomized clinical trial. METHODS Twenty-seven expressive writing and time management participants completed questionnaires prior to writing, following their fourth writing session, and 1 month later. We examined the effect of group differenc...

The main objective of this study was to investigate the biological function of β amyloid precursor protein (APP), in particular its nerve growth factor-like activity. We hypothesize that the extracellular domain containing the sequence RERMS, amino acids 328-332 of APP695, represents the active site for this function. Binding assays using peptide fragments of this domain have demonstrated speci...

Reported is the methodology of the semantic transformation of an initial user’s search query in the form of key words or key phrases to the resulting query composed of the relevant concepts of the domain ontology. Transformation methodology is based on incremental user profiling. The mapping of a user’s keywords to the concepts of the domain ontology is built according to the presented transfor...

Dispositional mindfulness is associated with lower levels of perceived stress, with increased emotional regulation and cognitive control proposed as mechanisms underlying these stress-buffering effects of mindfulness. Within aging, these controlled processes represent paradoxically divergent trajectories such that older adults exhibit reduced cognitive control capacities, while emotional regula...

BACKGROUND In the Norwegian context, higher mental distress has been reported for the non-Western immigrants compared to the ethnic Norwegians and Western immigrants. This high level of distress is often related to different socio-economic conditions in this group. No efforts have been made earlier to observe the impact of changed psychosocial conditions on the state of mental distress of these...

Genome sequencing of various individuals or isolates of the same species allows studying the polymorphism level of specific proteins and protein domains. Here we ask whether domains that are known to be involved in mediating protein-protein interactions show lower polymorphism than other domains. To this end we take advantage of a recent genome sequence dataset of 39 Saccahromyces cerevisiae st...

Secreted Semaphorin3A (Sema3A) proteins are known to act as diffusible and repellant axonal guidance cues during nervous system development. A receptor complex consisting of a Neuropilin and a Plexin-A mediates their effects. Plexin-A signal transduction has remained poorly defined despite the documented involvement of collapsin response mediator protein and molecule interacting with CasL prote...