BACKGROUND A 1,927-nm wavelength was recently added to the 1,550-nm erbium-doped fiber laser. This wavelength possesses a higher absorption coefficient for water than the 1,550-nm, conferring greater ability to target epidermal processes such as dyschromia. OBJECTIVE To evaluate the efficacy and safety of a novel 1,927-nm fractional thulium fiber laser in the treatment of melasma. METHODS F...

BACKGROUND Melasma is a common pigmentary disorder that remains resistant to available therapies. Facial resurfacing with the pulsed CO2 laser has been reported successful but requires significant downtime, and there is a risk of adverse sequelae. OBJECTIVE To determine if melasma will respond to a new treatment paradigm, fractional resurfacing. METHODS Ten female patients (Fitzpatrick skin...

Melasma represents a pigmentary disorder that is difficult to treat. This study aims to broadly review the use of ablative lasers (Er:YAG and CO2) in the treatment of melasma, presenting the level of evidence of studies published to date. A total of 75 patients were enrolled in four case series studies (n=39), one controlled clinical trial (n=6) and one randomized controlled clinical trial (n=3...

Background Hypermelanosis includes a diverse group of genetic and acquired skin anomalies that appear as darker, hyperpigmented areas. Melasma, in particular, is a hypermelanotic condition that affects sun-exposed skin in females. Whether this condition is acquired or genetic is still controversial. However, it clearly correlates with exposure to UV light, a genetic predisposition, and hormonal...

Melasma is an acquired chronic hyperpigmentation which mainly affects women on sun-exposed areas of the body, especially face in Fitzpatrick skin types III-V. The study setting at Dermatology Clinic NILES, Cairo University, Egypt. This aims to evaluate clinical efficacy and safety fractional ablative erbium:YAG Laser therapy versus chemical peeling treatment melasma. included 30 patients with m...

Aim: To compare the efficacy and safety of topical 3% tranexamic acid gel vs 35% glycolic peel in treatment melasma over face.
 Materials Methods: This is an open labelled, Randomised Controlled Trial(RCT) conducted on 60 patients. Patients were randomly divided equally into 2 groups – Group A B. used twice a day B patients treated with contact period 5 minutes once every weeks. assessed m...

Abbreviations: BC: Before Christ; UV: Ultraviolet; NCBI: National Center For Biotechnology Information; Mirna: Microrna; IL-1: Interleukin 1; MSH: Melanocyte Stimulating Hormone; ACTH: Adrenocorticotropic Hormone; LH: Luteinizing Hormone; FSH: Follicle-Stimulating Hormone; MC1R: Melanocortin Type 1 Receptor; ER: Estrogen Receptor ; PR :Progesterone Receptor; TPO: Thyroid Peroxidase; TSH: Thyroi...

*Corresponding author: Dr. Ilaria Muller, Clinical Lecturer, Centre for Endocrine and Diabetes Sciences, Institute of Molecular & Experimental Medicine, Cardiff University School of Medicine, Room 256, main building block C, second floor (C2 Link Corridor), University Hospital of Wales Heath Park, Cardiff, CF 14 4XN, UK, Tel: Tel: +44(0)29 2074 2182; Fax: +44(0)29 2074 4671; E-mail: ilaria.mull...