Hot melt extrusion is one of the most popular techniques for manufacturing amorphous solid dispersions (ASDs). Over few decades, it has transitioned from lab scale to commercial with various products in market. The current review aims at summarizing considerations formulation development ASDs using HME. Various types Type I IV are discussed along state drug and polymeric carrier each type. Also...

Infectious disease outbreaks within healthcare facilities can exacerbate patient illness and, in some cases, be fatal. Contaminated surfaces and medical devices act as a reservoir for transmission of pathogens have been linked to the rising incidence healthcare-acquired infections. Antimicrobial reduce microbial contamination emerged crucial component infection control recent years. The aim thi...

This study fabricated polylactic acid (PLA)/kenaf cellulose fiber biocomposite filaments via melt-extrusion process. Kenaf fibers (KF) were chemically extracted from locally grown kenaf plants and used as reinforcement. Moreover, the KF was then treated with tetraethyl orthosilicate (TEOS), so-called KFs, to improve compatibility between PLA matrix. Also, plasticizers (polyethylene glycol) inco...

The mechanical and thermal properties of injection-molded recycled polyethylene were studied, specifically with respect to the influence large-scale washing melt-compounding from post-consumer packaging waste. Three types materials studied: those taken after sorting, sorting washing, melt-compounding, including melt-filtration, all a material flow. further processed on laboratory scale compared...

UNLABELLED Dairy proteins are amenable to structural modifications induced by high temperature, shear, and moisture; in particular, whey proteins can change conformation to new unfolded states. The change in protein state is a basis for creating new foods. The dairy products, nonfat dried milk (NDM), whey protein concentrate (WPC), and whey protein isolate (WPI) were modified using a twin-screw...

Hot melt extrusion has gained considerable attention as a novel technique for taste masking of bitter APIs. The aim of this study was to investigate whether hot melt extrusion could be used to develop taste masked formulations of isoniazid and also to evaluate and correlate different taste assessment methods Two polymers with different physico-chemical properties, Soluplus and Eudragit E-PO wer...

Irradiation of polymers is one of the most effective and economical methods for modifying their properties and for changing their applications. In this study, an extrusion grade polypropylene (PP) was treated by electron beam irradiation to produce a PP suitable for injection molding. Irradiation was carried out at different doses (0-80 kGy) under atmosphere air and at ambient temperature. Melt...

Diethylethanolamine derivativetablets, manufactured by direct compression, do not possess adequate quality attributes. Granulation of excipients makes it possible to improve the fluidity mixture and increase shelf-life tablets, however organization technological process in production is expensive. Melt extrusion stability substance obtain high-quality tablets with a 2 years. This approach prefe...