BACKROUND ~This study used two standardized methods to evaluate anti-PLA2R antibody in serum of primary membranous nephropathy (PMN) among Chinese patients to determine  Anti-PLA2R antibody distribution and whether immunological reactivity reflected by antibody titer correlates with kidney function parameters. MATERIAL AND METHOD ~Overall, 82 subjects with biopsy-proven primary membranous nephr...

BACKGROUND Treatment of idiopathic membranous nephropathy with nephrotic syndrome is still controversial. There is currently little known about the clinical use of renal biomarkers which may explain contradictory results obtained from clinical trials. In order to assess whether IgG-uria can predict the outcome in membranous nephropathy, we examined the value of baseline EF-IgG in predicting rem...

Just over 50 years ago, the late David Jones1 iden­ tified (using the periodic acid–Schiff and meth­ enamine silver stains) the unique glomerular pathologic features of membranous nephropathy, thus distinguishing it from other causes of “ne­ phrotic glomerulonephritis.” Subsequent immuno­ fluorescence and electron­microscopical studies established that membranous nephropathy was also characteri...

transmembrane glycoprotein related to the C‐type animal lectin family like the mannose receptor. More recent observations, revealed that antibodies to the PLA2r are IgG4.[24,31,32] These IgG4 antibodies can be identified in the glomerular immune complexes and they co‐localize with PLA2r. Moreover, in secondary forms of membranous nephropathy, such IgG4 antibodies are lacking or less prevalent.[...

Chronic viral hepatitis B and C may associate different extrahepatic manifestations and renal disease is the most frequent. Kidney damage is represented in most cases by glomerulopathies, which include membranous nephropathy, membranoproliferative glomerulonephritis (MPGN), IgA nephropathy, focal and segmental glomerulosclerosis and diabetic nephropathy. We conducted a retrospective study on 63...

BACKGROUND Membranous nephropathy (MN) is the leading cause of nephrotic syndrome in adults. MN is a clinically heterogeneous disease and it is difficult to accurately predict outcomes (including end stage renal failure) at presentation and whom to treat with potentially toxic therapies. We aimed to identify factors predicting outcome in MN in our cohort from two large tertiary London units by ...

Objective: To describe a possible association between Graves’ disease and nephrotic syndrome secondary to membranous nephropathy and to review the literature related to renal diseases in patients with Graves’ disease. Methods: The clinical, laboratory, and renal biopsy findings in a patient with Graves’ disease and membranous nephropathy are discussed. Results: 50 Y, Male, non diabetic, non hyp...

Introduction: Membranous nephropathy (MN) is the most common causes of the nephrotic syndrome in nondiabetic, Caucasian adults. Pauci-immune necrotizing and crescentic glomerulonephritis (PNCGN) typically present with rapidly progressive glomerulonephritis. Coexistent MN and PNCGN is a rare occurrence. We report a case of both MPOand PR3-ANCA associated NCGN with MN that presented as rapidly pr...

Idiopathic membranous glomerulonephropathy is a well defined clinical and pathological entity (Cluck et al, 1973). It is postulated to be an immune-complex disease. There seems to be some variation in the life expectancy in this group of patients, nonetheless most agree that slow progression to renal failure is usual. Evolution of membranous nephropathy to a rapidly progressive crescentic glome...

Renal involvement in systemic lupus erythematosus (SLE) is usually immune complex mediated and may have multiple different presentations. Pauci-immune necrotizing and crescentic glomerulonephritis (NCGN) refers to extensive glomerular inflammation with few or no immune deposits that may result in rapid decline in renal function. We report a case of a 79-year-old Hispanic male with a history of ...