نتایج جستجو برای: meningeal melanomas
تعداد نتایج: 10010 فیلتر نتایج به سال:
PURPOSE We recently identified a KIT exon 11 mutation in an anorectal melanoma of a patient who had an excellent response to treatment with imatinib. To determine the frequency of KIT mutations across melanoma subtypes, we surveyed a large series of tumors. EXPERIMENTAL DESIGN One hundred eighty-nine melanomas were screened for mutations in KIT exons 11, 13, and 17. KIT copy number was assess...
It has been observed that a patient’s “normal” moles resemble each other clinically. This concept also applies to dermoscopic observations, as shown by our previous demonstration that an individual’s nevi tend to have one to three predominant overall dermoscopic patterns [1]. A recent study investigated and compared the dermoscopic patterns of multiple primary melanomas (MPMs) in a large series...
Abstract Sinonasal malignant melanoma is a rare, aggressive tumor, associated with poor prognosis, accounting for 8-15% of all head and neck melanomas 0.5-2% melanomas. The diagnosis given by histopathological immunological examination. Elective treatment consists surgical excision free resection borders, adjuvant chemotherapy / radiotherapy immunotherapy checkpoint inhibitors can be used to co...
OBJECTIVES To examine the role of sequential dermoscopy imaging in detecting incipient melanoma and to elucidate the impact of length of follow-up on the relevance of observed changes. DESIGN Baseline and follow-up images of melanomas and melanocytic nevi excised only because of changes across time were inspected on a computer screen and assessed according to prospectively defined criteria. L...
Malignant melanomas of the vulva are rare tumours which constitute only 5-10% of all vulvar cancers but are the second commonest vulvar malignancy after squamous carcinomas. Almost all vulvar naevi are of the junctional type from which melanomas are believed to arise and this may explain why in women, 3-5% of melanomas occur in the vulva though it occupies only 1-2% of the body surface area. Vu...
The discovery of activating oncogenic BRAF V600E mutations in the majority of melanomas has not yet been translated into more effective therapy. The failure of agents may be due to lack of sufficiently targeted therapeutics, but is more likely based on the activation of multiple oncogenic pathways in melanomas in addition to the mitogen-activated protein kinase signaling pathway. In contrast, t...
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