Introduction and Objective: Bilateral bleeding found over healthy eyes, in healthy pubertal females, that is cyclic and concomitant with menses, is a very rare event. Rarer is its association with cyclic epistaxis and cyclic bleeding from ears and skin bleeding. We present a series of such cases and a trial to diagnose and manage them. Those cases remained undiagnosed for years. We also present...

OBJECTIVE Clinicians should show an awareness on the menstrual characteristics of adolescent girls which may differ from adults in some aspects. To define menstrual cycle features among high school girls residing in a city center in southeastern Turkey. METHODS A cross-sectional survey was conducted on 1256 girls attending a high school located in the city center of Elazığ, Turkey. Data from ...

BACKGROUND This double-blind trial investigated the efficacy and safety of estradiol valerate/dienogest (E(2)V/DNG) for the treatment of heavy menstrual bleeding without recognizable organic pathology. METHODS Otherwise healthy women with idiopathic heavy, prolonged or frequent menstrual bleeding, confirmed during a 90-day run-in phase, were randomized (2:1) according to a permuted-block, com...

BACKGROUND The purpose of this study was to quantify the impact of estradiol-valerate/dienogest (E(2)V/DNG; Qlaira(®)/Natazia(®)) on work productivity and activities of daily living in European and Australian women with heavy menstrual bleeding. METHODS Women aged 18-54 years with a confirmed diagnosis of heavy menstrual bleeding and no recognizable pathology were recruited across nine Europe...

CONTEXT Although many research studies have documented the relationship between menstrual side effects of contraceptives and discontinuation of use, few have sought to identify factors that predispose women to discontinue because of changes in bleeding patterns. Such information is important to enable family planning providers to better help women and couples choose appropriate methods and use ...

OBJECTIVE To determine the relative effectiveness of second generation ablation techniques in the treatment of heavy menstrual bleeding. DESIGN Network meta-analysis on the primary outcome measures of amenorrhoea, heavy bleeding, and patients' dissatisfaction with treatment. DATA SOURCES Nineteen randomised controlled trials (involving 3287 women) were identified through electronic searches...

OBJECTIVE To compare the effectiveness of nonsurgical abnormal uterine bleeding treatments for bleeding control, quality of life (QOL), pain, sexual health, patient satisfaction, additional treatments needed, and adverse events. DATA SOURCES MEDLINE, Cochrane databases, and Clinicaltrials.gov were searched from inception to May 2012. We included randomized controlled trials of nonsurgical tre...

Menstruation is a phenomenon unique to the females. Menstruation, the periodic vaginal bleeding that occurs with the shedding of the uterine mucosa, is one of the important signs of puberty and occurs one or two years following appearance of secondary sexual characteristics. The first menstruation (menarche) occurs between 11 and 15 years with a mean age of 13 years. Once established, every mat...

Objective To determine the relative effectiveness of second generation ablation techniques in the treatment of heavy menstrual bleeding. Design Network meta-analysis on the primary outcome measures of amenorrhoea, heavy bleeding, and patients’ dissatisfaction with treatment. Data sources Nineteen randomised controlled trials (involving 3287 women) were identified through electronic searches of ...