Sandhoff disease (SD) is an inherited lysosomal storage disease caused by a β-hexosaminidase deficiency involving excessive accumulation of undegraded substrates, including GM2 ganglioside, which leads to neurological symptoms, such as mental retardation, spasms and quadriplegia. Macrophage inflammatory protein-1α (MIP-1α) is a crucial factor for microglia-mediated neuroinflammation in the onse...

Surgically placed shunts have proven useful in diverting excess accumulation of cerebrospinal fluid. The properly functioning shunt prevents increased intracranial pressure, gross craniofacial distortion, and the development of mental retardation, all of which have always been associated with the untreated hydrocephalic patient. The postoperative complication of microbial colonization of shunts...

Canavan disease (CD) is an autosomal recessive disorder, characterized by spongy degeneration of the brain. Patients with CD have aspartoacylase (ASPA) deficiency, which results accumulation of N-acetylaspartic acid (NAA) in the brain and elevated excretion of urinary NAA. Clinically, patients with CD have macrocephaly, mental retardation and hypotonia. A knockout mouse for CD which was enginee...

• Wisdom — which comes from the accumulation of experience within a framework of EIA knowledge and understanding; • Creativity — the ability to produce new ideas and insights to address established or emerging challenges; • Innovation — the application of wisdom and creativity to make positive changes that resolve problems; • Courage — the mental or moral strength to remain true to our principl...

Inherited metabolic diseases are a heterogeneous group of diseases caused by a punctual defect in cell metabolism, resulting in the accumulation of toxic intermediate metabolites or in the lack of important biomolecules for adequate cell functioning. D-glyceric aciduria is an inherited disease caused by a deficiency of glycerate 2-kinase activity, whose pathophysiological mechanisms remain unkn...

background: sediments are inseparable fractions of wetland ecosystems that work as a his-torical archive in the process of recording heavy metal aggregation changes. this study was carried out for assessing co, ni, and zn in sediment samples of mighan wetland using geo-accumulation index in 2013. methods:the sediment samples were taken from 11 stations. the samples were subjected to bulk digest...

the purpose of this study was the introduction of seed accumulation index as a new approach in the evaluation of soil seed bank consistency in the populus caspica in noor reserved forest park. sampling were made above ground vegetation at peak vegetation cover during june 2010 by systematic- selective method. soil samples were collected during late june, late november and early february by hamm...

abstract- olive (olea europaea l.) is one of the most valuable and widespread fruit trees in iran. salt stress-induced changes in membrane stability, photosynthesis and antioxidant enzyme activity were examined on four olive cultivars (dakal, shiraz, zard and amigdalifolia) by emphasizing the correlation between measured parameters and ion (k+, na+) accumulation. plants were subjected to four s...

providing healthy food and protecting sources from pollution has been one of the concerns of human societies and decision – making centers so that protecting food from pollution, detecting sources of pollution and measuring them become important. because of nutritive and political significance of grape in this area, extensive use of leaf and fruit of this plant, developing urban areas around gr...